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Hyaluronan fragments induce IFNβ via a novel TLR4-TRIF-TBK1-IRF3-dependent pathway

BACKGROUND: The extracellular matrix plays a critical role in insuring tissue integrity and water homeostasis. However, breakdown products of the extracellular matrix have emerged as endogenous danger signals, designed to rapidly activate the immune system against a potential pathogen breach. Type I...

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Detalles Bibliográficos
Autores principales:	Black, Katharine E, Collins, Samuel L, Hagan, Robert S, Hamblin, Mark J, Chan-Li, Yee, Hallowell, Robert W, Powell, Jonathan D, Horton, Maureen R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682892/ https://www.ncbi.nlm.nih.gov/pubmed/23721397 http://dx.doi.org/10.1186/1476-9255-10-23

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