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Zinc Finger Nuclease Mediated Knockout of ADP-Dependent Glucokinase in Cancer Cell Lines: Effects on Cell Survival and Mitochondrial Oxidative Metabolism

Zinc finger nucleases (ZFN) are powerful tools for editing genes in cells. Here we use ZFNs to interrogate the biological function of ADPGK, which encodes an ADP-dependent glucokinase (ADPGK), in human tumour cell lines. The hypothesis we tested is that ADPGK utilises ADP to phosphorylate glucose un...

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Detalles Bibliográficos
Autores principales:	Richter, Susan, Morrison, Shona, Connor, Tim, Su, Jiechuang, Print, Cristin G., Ronimus, Ron S., McGee, Sean L., Wilson, William R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683018/ https://www.ncbi.nlm.nih.gov/pubmed/23799003 http://dx.doi.org/10.1371/journal.pone.0065267

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