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Aspergillus felis sp. nov., an Emerging Agent of Invasive Aspergillosis in Humans, Cats, and Dogs
We describe a novel heterothallic species in Aspergillus section Fumigati, namely A. felis (neosartorya-morph) isolated from three host species with invasive aspergillosis including a human patient with chronic invasive pulmonary aspergillosis, domestic cats with invasive fungal rhinosinusitis and a...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683053/ https://www.ncbi.nlm.nih.gov/pubmed/23798996 http://dx.doi.org/10.1371/journal.pone.0064871 |
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author | Barrs, Vanessa R. van Doorn, Tineke M. Houbraken, Jos Kidd, Sarah E. Martin, Patricia Pinheiro, Maria Dolores Richardson, Malcolm Varga, Janos Samson, Robert A. |
author_facet | Barrs, Vanessa R. van Doorn, Tineke M. Houbraken, Jos Kidd, Sarah E. Martin, Patricia Pinheiro, Maria Dolores Richardson, Malcolm Varga, Janos Samson, Robert A. |
author_sort | Barrs, Vanessa R. |
collection | PubMed |
description | We describe a novel heterothallic species in Aspergillus section Fumigati, namely A. felis (neosartorya-morph) isolated from three host species with invasive aspergillosis including a human patient with chronic invasive pulmonary aspergillosis, domestic cats with invasive fungal rhinosinusitis and a dog with disseminated invasive aspergillosis. Disease in all host species was often refractory to aggressive antifungal therapeutic regimens. Four other human isolates previously reported as A. viridinutans were identified as A. felis on comparative sequence analysis of the partial β-tubulin and/or calmodulin genes. A. felis is a heterothallic mold with a fully functioning reproductive cycle, as confirmed by mating-type analysis, induction of teleomorphs within 7 to 10 days in vitro and ascospore germination. Phenotypic analyses show that A. felis can be distinguished from the related species A. viridinutans by its ability to grow at 45°C and from A. fumigatus by its inability to grow at 50°C. Itraconazole and voriconazole cross-resistance was common in vitro. |
format | Online Article Text |
id | pubmed-3683053 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-36830532013-06-24 Aspergillus felis sp. nov., an Emerging Agent of Invasive Aspergillosis in Humans, Cats, and Dogs Barrs, Vanessa R. van Doorn, Tineke M. Houbraken, Jos Kidd, Sarah E. Martin, Patricia Pinheiro, Maria Dolores Richardson, Malcolm Varga, Janos Samson, Robert A. PLoS One Research Article We describe a novel heterothallic species in Aspergillus section Fumigati, namely A. felis (neosartorya-morph) isolated from three host species with invasive aspergillosis including a human patient with chronic invasive pulmonary aspergillosis, domestic cats with invasive fungal rhinosinusitis and a dog with disseminated invasive aspergillosis. Disease in all host species was often refractory to aggressive antifungal therapeutic regimens. Four other human isolates previously reported as A. viridinutans were identified as A. felis on comparative sequence analysis of the partial β-tubulin and/or calmodulin genes. A. felis is a heterothallic mold with a fully functioning reproductive cycle, as confirmed by mating-type analysis, induction of teleomorphs within 7 to 10 days in vitro and ascospore germination. Phenotypic analyses show that A. felis can be distinguished from the related species A. viridinutans by its ability to grow at 45°C and from A. fumigatus by its inability to grow at 50°C. Itraconazole and voriconazole cross-resistance was common in vitro. Public Library of Science 2013-06-14 /pmc/articles/PMC3683053/ /pubmed/23798996 http://dx.doi.org/10.1371/journal.pone.0064871 Text en © 2013 Barrs et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Barrs, Vanessa R. van Doorn, Tineke M. Houbraken, Jos Kidd, Sarah E. Martin, Patricia Pinheiro, Maria Dolores Richardson, Malcolm Varga, Janos Samson, Robert A. Aspergillus felis sp. nov., an Emerging Agent of Invasive Aspergillosis in Humans, Cats, and Dogs |
title |
Aspergillus felis sp. nov., an Emerging Agent of Invasive Aspergillosis in Humans, Cats, and Dogs |
title_full |
Aspergillus felis sp. nov., an Emerging Agent of Invasive Aspergillosis in Humans, Cats, and Dogs |
title_fullStr |
Aspergillus felis sp. nov., an Emerging Agent of Invasive Aspergillosis in Humans, Cats, and Dogs |
title_full_unstemmed |
Aspergillus felis sp. nov., an Emerging Agent of Invasive Aspergillosis in Humans, Cats, and Dogs |
title_short |
Aspergillus felis sp. nov., an Emerging Agent of Invasive Aspergillosis in Humans, Cats, and Dogs |
title_sort | aspergillus felis sp. nov., an emerging agent of invasive aspergillosis in humans, cats, and dogs |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683053/ https://www.ncbi.nlm.nih.gov/pubmed/23798996 http://dx.doi.org/10.1371/journal.pone.0064871 |
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