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Asparagine Substitution at PB2 Residue 701 Enhances the Replication, Pathogenicity, and Transmission of the 2009 Pandemic H1N1 Influenza A Virus

The 2009/2010 pandemic influenza virus (H1N1pdm) contains an avian-lineage PB2 gene that lacks E627K and D701N substitutions important in the pathogenesis and transmission of avian-origin viruses in humans or other mammals. Previous studies have shown that PB2-627K is not necessary because of a comp...

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Detalles Bibliográficos
Autores principales:	Zhou, Bin, Pearce, Melissa B., Li, Yan, Wang, Jieru, Mason, Robert J., Tumpey, Terrence M., Wentworth, David E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683066/ https://www.ncbi.nlm.nih.gov/pubmed/23799150 http://dx.doi.org/10.1371/journal.pone.0067616

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