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The Rho-GEF Trio regulates a novel pro-inflammatory pathway through the transcription factor Ets2

Inflammation is characterized by endothelium that highly expresses numerous adhesion molecules to trigger leukocyte extravasation. Central to this event is increased gene transcription. Small Rho-GTPases not only control the actin cytoskeleton, but are also implicated in gene regulation. However, in...

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Detalles Bibliográficos
Autores principales: Van Rijssel, Jos, Timmerman, Ilse, Van Alphen, Floris P. J., Hoogenboezem, Mark, Korchynskyi, Olexandr, Geerts, Dirk, Geissler, Judy, Reedquist, Kris A., Niessen, Hans W. M., Van Buul, Jaap D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683159/
https://www.ncbi.nlm.nih.gov/pubmed/23789107
http://dx.doi.org/10.1242/bio.20134382