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Noninvasive indicators of atherosclerosis in subclinical hypothyroidism
INTRODUCTION: Cardiovascular system is rich in thyroid hormone receptors and is one of the major sites of action for thyroid hormones. However, the effect of subclinical hypothyroidism (SCH) on atherosclerosis has not been cleared yet. MATERIALS AND METHODS: SCH is defined as high thyroid-stimulatin...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683203/ https://www.ncbi.nlm.nih.gov/pubmed/23776901 http://dx.doi.org/10.4103/2230-8210.109708 |
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author | Kilic, Ismail Dogu Tanriverdi, Halil Fenkci, Semin Akin, Fulya Uslu, Sukriye Kaftan, Asuman |
author_facet | Kilic, Ismail Dogu Tanriverdi, Halil Fenkci, Semin Akin, Fulya Uslu, Sukriye Kaftan, Asuman |
author_sort | Kilic, Ismail Dogu |
collection | PubMed |
description | INTRODUCTION: Cardiovascular system is rich in thyroid hormone receptors and is one of the major sites of action for thyroid hormones. However, the effect of subclinical hypothyroidism (SCH) on atherosclerosis has not been cleared yet. MATERIALS AND METHODS: SCH is defined as high thyroid-stimulating hormone (TSH) levels in the presence of normal serum T4 and T3 levels. A total of 32 patients with SCH and 29 controls were included in the study. Carotid intima-media thickness, flow-mediated dilatation, and aortic distensibility were compared between the groups. RESULTS: FMD was lower in patients with SCH than in controls. GTN-induced vasodilatation was similar in the patients with SCH and controls. There was no statistically significant difference between the patients with SCH and controls with respect to CIMT and aortic distensibility. CONCLUSION: SCH is associated with endothelial dysfunction as established by FMD. Inconsistent results of CIMT and aortic stiffness can be explained by these parameters being measures of structural changes whereas FMD is a dynamic measure that reflects the impact of both acute and chronic influences on endothelial function. |
format | Online Article Text |
id | pubmed-3683203 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-36832032013-06-17 Noninvasive indicators of atherosclerosis in subclinical hypothyroidism Kilic, Ismail Dogu Tanriverdi, Halil Fenkci, Semin Akin, Fulya Uslu, Sukriye Kaftan, Asuman Indian J Endocrinol Metab Original Article INTRODUCTION: Cardiovascular system is rich in thyroid hormone receptors and is one of the major sites of action for thyroid hormones. However, the effect of subclinical hypothyroidism (SCH) on atherosclerosis has not been cleared yet. MATERIALS AND METHODS: SCH is defined as high thyroid-stimulating hormone (TSH) levels in the presence of normal serum T4 and T3 levels. A total of 32 patients with SCH and 29 controls were included in the study. Carotid intima-media thickness, flow-mediated dilatation, and aortic distensibility were compared between the groups. RESULTS: FMD was lower in patients with SCH than in controls. GTN-induced vasodilatation was similar in the patients with SCH and controls. There was no statistically significant difference between the patients with SCH and controls with respect to CIMT and aortic distensibility. CONCLUSION: SCH is associated with endothelial dysfunction as established by FMD. Inconsistent results of CIMT and aortic stiffness can be explained by these parameters being measures of structural changes whereas FMD is a dynamic measure that reflects the impact of both acute and chronic influences on endothelial function. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3683203/ /pubmed/23776901 http://dx.doi.org/10.4103/2230-8210.109708 Text en Copyright: © Indian Journal of Endocrinology and Metabolism http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kilic, Ismail Dogu Tanriverdi, Halil Fenkci, Semin Akin, Fulya Uslu, Sukriye Kaftan, Asuman Noninvasive indicators of atherosclerosis in subclinical hypothyroidism |
title | Noninvasive indicators of atherosclerosis in subclinical hypothyroidism |
title_full | Noninvasive indicators of atherosclerosis in subclinical hypothyroidism |
title_fullStr | Noninvasive indicators of atherosclerosis in subclinical hypothyroidism |
title_full_unstemmed | Noninvasive indicators of atherosclerosis in subclinical hypothyroidism |
title_short | Noninvasive indicators of atherosclerosis in subclinical hypothyroidism |
title_sort | noninvasive indicators of atherosclerosis in subclinical hypothyroidism |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683203/ https://www.ncbi.nlm.nih.gov/pubmed/23776901 http://dx.doi.org/10.4103/2230-8210.109708 |
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