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Low triiodothyronine predicts mortality in critically ill patients

OBJECTIVE: Alteration in thyroid hormones are seen in critically ill patients admitted to intensive care units. Our objective was to study the thyroid hormone profile, prolactin and, glycosylated hemoglobin (HbA1c) at admission and analyze their correlation with mortality. MATERIALS AND METHODS: In...

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Autores principales: Kumar, K. V. S. Hari, Kapoor, Umesh, Kalia, Richa, Chandra, N. S. Ajai, Singh, Parikshit, Nangia, R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683206/
https://www.ncbi.nlm.nih.gov/pubmed/23776904
http://dx.doi.org/10.4103/2230-8210.109715
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author Kumar, K. V. S. Hari
Kapoor, Umesh
Kalia, Richa
Chandra, N. S. Ajai
Singh, Parikshit
Nangia, R.
author_facet Kumar, K. V. S. Hari
Kapoor, Umesh
Kalia, Richa
Chandra, N. S. Ajai
Singh, Parikshit
Nangia, R.
author_sort Kumar, K. V. S. Hari
collection PubMed
description OBJECTIVE: Alteration in thyroid hormones are seen in critically ill patients admitted to intensive care units. Our objective was to study the thyroid hormone profile, prolactin and, glycosylated hemoglobin (HbA1c) at admission and analyze their correlation with mortality. MATERIALS AND METHODS: In this single centre, prospective, observational study, 100 consecutive patients (52M; 48F) admitted to medical ICU irrespective of diagnosis were included. Patients with previous thyroid disorders and drugs affecting thyroid function were excluded. All participants underwent complete physical examination and a single fasting blood sample obtained at admission was analyzed for total triiodothyronine (T3), total thyroxine (T4), thyroid stimulating hormone (TSH), HbA1c, and prolactin. The patients were divided into two groups: Group 1 – survivors (discharged from the hospital) and Group 2 – nonsurvivors (patients succumbed to their illness inside the hospital). The data were analyzed by appropriate statistical methods and a P-value of <0.05 was considered significant. RESULTS: The mean age of the participants was 58.7 ± 16.9 years and the mean duration of ICU stay was 3.3 ± 3.1 days. A total of 64 patients survived, whereas remaining 36 succumbed to their illness. The baseline demographic profile was comparable between survivors and nonsurvivors. Nonsurvivors had low T3 when compared with survivors (49.1 ± 32.7 vs. 66.2 ± 30.1, P = 0.0044). There was no significant difference observed between survivors and nonsurvivors with respect to T4, TSH, HbA1c, and prolactin. CONCLUSION: Our study showed that low T3 is an important marker of mortality in critically ill patients. Admission HbA1c, prolactin, T4, and TSH did not vary between survivors and nonsurvivors.
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spelling pubmed-36832062013-06-17 Low triiodothyronine predicts mortality in critically ill patients Kumar, K. V. S. Hari Kapoor, Umesh Kalia, Richa Chandra, N. S. Ajai Singh, Parikshit Nangia, R. Indian J Endocrinol Metab Original Article OBJECTIVE: Alteration in thyroid hormones are seen in critically ill patients admitted to intensive care units. Our objective was to study the thyroid hormone profile, prolactin and, glycosylated hemoglobin (HbA1c) at admission and analyze their correlation with mortality. MATERIALS AND METHODS: In this single centre, prospective, observational study, 100 consecutive patients (52M; 48F) admitted to medical ICU irrespective of diagnosis were included. Patients with previous thyroid disorders and drugs affecting thyroid function were excluded. All participants underwent complete physical examination and a single fasting blood sample obtained at admission was analyzed for total triiodothyronine (T3), total thyroxine (T4), thyroid stimulating hormone (TSH), HbA1c, and prolactin. The patients were divided into two groups: Group 1 – survivors (discharged from the hospital) and Group 2 – nonsurvivors (patients succumbed to their illness inside the hospital). The data were analyzed by appropriate statistical methods and a P-value of <0.05 was considered significant. RESULTS: The mean age of the participants was 58.7 ± 16.9 years and the mean duration of ICU stay was 3.3 ± 3.1 days. A total of 64 patients survived, whereas remaining 36 succumbed to their illness. The baseline demographic profile was comparable between survivors and nonsurvivors. Nonsurvivors had low T3 when compared with survivors (49.1 ± 32.7 vs. 66.2 ± 30.1, P = 0.0044). There was no significant difference observed between survivors and nonsurvivors with respect to T4, TSH, HbA1c, and prolactin. CONCLUSION: Our study showed that low T3 is an important marker of mortality in critically ill patients. Admission HbA1c, prolactin, T4, and TSH did not vary between survivors and nonsurvivors. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3683206/ /pubmed/23776904 http://dx.doi.org/10.4103/2230-8210.109715 Text en Copyright: © Indian Journal of Endocrinology and Metabolism http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kumar, K. V. S. Hari
Kapoor, Umesh
Kalia, Richa
Chandra, N. S. Ajai
Singh, Parikshit
Nangia, R.
Low triiodothyronine predicts mortality in critically ill patients
title Low triiodothyronine predicts mortality in critically ill patients
title_full Low triiodothyronine predicts mortality in critically ill patients
title_fullStr Low triiodothyronine predicts mortality in critically ill patients
title_full_unstemmed Low triiodothyronine predicts mortality in critically ill patients
title_short Low triiodothyronine predicts mortality in critically ill patients
title_sort low triiodothyronine predicts mortality in critically ill patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683206/
https://www.ncbi.nlm.nih.gov/pubmed/23776904
http://dx.doi.org/10.4103/2230-8210.109715
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