Mouse Prostate Epithelial Luminal Cells Lineage Originate in the Basal Layer Where the Primitive Stem/Early Progenitor Cells Reside: Implications for Identifying Prostate Cancer Stem Cells

Prostate stem cells are thought to be responsible for generation of all prostate epithelial cells and for tissue maintenance. The lineage relationship between basal and luminal cells in the prostate is not well clarified. We developed a mouse model to trace cell fate and a mouse model with a slowly...

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Detalles Bibliográficos
Autores principales: Zhou, Jianjun, Feigenbaum, Lionel, Yee, Carole, Song, Hongbin, Yates, Clayton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683430/
https://www.ncbi.nlm.nih.gov/pubmed/23819124
http://dx.doi.org/10.1155/2013/913179
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author Zhou, Jianjun
Feigenbaum, Lionel
Yee, Carole
Song, Hongbin
Yates, Clayton
author_facet Zhou, Jianjun
Feigenbaum, Lionel
Yee, Carole
Song, Hongbin
Yates, Clayton
author_sort Zhou, Jianjun
collection PubMed
description Prostate stem cells are thought to be responsible for generation of all prostate epithelial cells and for tissue maintenance. The lineage relationship between basal and luminal cells in the prostate is not well clarified. We developed a mouse model to trace cell fate and a mouse model with a slowly cycling cell label to provide insight into this question. The results obtained indicate that putative mouse prostate stem cells are likely to reside in the basal layer.
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spelling pubmed-36834302013-07-01 Mouse Prostate Epithelial Luminal Cells Lineage Originate in the Basal Layer Where the Primitive Stem/Early Progenitor Cells Reside: Implications for Identifying Prostate Cancer Stem Cells Zhou, Jianjun Feigenbaum, Lionel Yee, Carole Song, Hongbin Yates, Clayton Biomed Res Int Research Article Prostate stem cells are thought to be responsible for generation of all prostate epithelial cells and for tissue maintenance. The lineage relationship between basal and luminal cells in the prostate is not well clarified. We developed a mouse model to trace cell fate and a mouse model with a slowly cycling cell label to provide insight into this question. The results obtained indicate that putative mouse prostate stem cells are likely to reside in the basal layer. Hindawi Publishing Corporation 2013 2013-06-01 /pmc/articles/PMC3683430/ /pubmed/23819124 http://dx.doi.org/10.1155/2013/913179 Text en Copyright © 2013 Jianjun Zhou et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhou, Jianjun
Feigenbaum, Lionel
Yee, Carole
Song, Hongbin
Yates, Clayton
Mouse Prostate Epithelial Luminal Cells Lineage Originate in the Basal Layer Where the Primitive Stem/Early Progenitor Cells Reside: Implications for Identifying Prostate Cancer Stem Cells
title Mouse Prostate Epithelial Luminal Cells Lineage Originate in the Basal Layer Where the Primitive Stem/Early Progenitor Cells Reside: Implications for Identifying Prostate Cancer Stem Cells
title_full Mouse Prostate Epithelial Luminal Cells Lineage Originate in the Basal Layer Where the Primitive Stem/Early Progenitor Cells Reside: Implications for Identifying Prostate Cancer Stem Cells
title_fullStr Mouse Prostate Epithelial Luminal Cells Lineage Originate in the Basal Layer Where the Primitive Stem/Early Progenitor Cells Reside: Implications for Identifying Prostate Cancer Stem Cells
title_full_unstemmed Mouse Prostate Epithelial Luminal Cells Lineage Originate in the Basal Layer Where the Primitive Stem/Early Progenitor Cells Reside: Implications for Identifying Prostate Cancer Stem Cells
title_short Mouse Prostate Epithelial Luminal Cells Lineage Originate in the Basal Layer Where the Primitive Stem/Early Progenitor Cells Reside: Implications for Identifying Prostate Cancer Stem Cells
title_sort mouse prostate epithelial luminal cells lineage originate in the basal layer where the primitive stem/early progenitor cells reside: implications for identifying prostate cancer stem cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683430/
https://www.ncbi.nlm.nih.gov/pubmed/23819124
http://dx.doi.org/10.1155/2013/913179
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