FSH and TSH in the Regulation of Bone Mass: The Pituitary/Immune/Bone Axis

Recent evidences have highlighted that the pituitary hormones have profound effects on bone, so that the pituitary-bone axis is now becoming an important issue in the skeletal biology. Here, we discuss the topical evidence about the dysfunction of the pituitary-bone axis that leads to osteoporotic b...

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Detalles Bibliográficos
Autores principales: Colaianni, Graziana, Cuscito, Concetta, Colucci, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683445/
https://www.ncbi.nlm.nih.gov/pubmed/23818914
http://dx.doi.org/10.1155/2013/382698
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author Colaianni, Graziana
Cuscito, Concetta
Colucci, Silvia
author_facet Colaianni, Graziana
Cuscito, Concetta
Colucci, Silvia
author_sort Colaianni, Graziana
collection PubMed
description Recent evidences have highlighted that the pituitary hormones have profound effects on bone, so that the pituitary-bone axis is now becoming an important issue in the skeletal biology. Here, we discuss the topical evidence about the dysfunction of the pituitary-bone axis that leads to osteoporotic bone loss. We will explore the context of FSH and TSH hormones arguing their direct or indirect role in bone loss. In addition, we will focus on the knowledge that both FSH and TSH have influence on proinflammatory and proosteoclastogenic cytokine expression, such as TNFα and IL-1, underlining the correlation of pituitary-bone axis to the immune system.
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spelling pubmed-36834452013-07-01 FSH and TSH in the Regulation of Bone Mass: The Pituitary/Immune/Bone Axis Colaianni, Graziana Cuscito, Concetta Colucci, Silvia Clin Dev Immunol Review Article Recent evidences have highlighted that the pituitary hormones have profound effects on bone, so that the pituitary-bone axis is now becoming an important issue in the skeletal biology. Here, we discuss the topical evidence about the dysfunction of the pituitary-bone axis that leads to osteoporotic bone loss. We will explore the context of FSH and TSH hormones arguing their direct or indirect role in bone loss. In addition, we will focus on the knowledge that both FSH and TSH have influence on proinflammatory and proosteoclastogenic cytokine expression, such as TNFα and IL-1, underlining the correlation of pituitary-bone axis to the immune system. Hindawi Publishing Corporation 2013 2013-05-30 /pmc/articles/PMC3683445/ /pubmed/23818914 http://dx.doi.org/10.1155/2013/382698 Text en Copyright © 2013 Graziana Colaianni et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Colaianni, Graziana
Cuscito, Concetta
Colucci, Silvia
FSH and TSH in the Regulation of Bone Mass: The Pituitary/Immune/Bone Axis
title FSH and TSH in the Regulation of Bone Mass: The Pituitary/Immune/Bone Axis
title_full FSH and TSH in the Regulation of Bone Mass: The Pituitary/Immune/Bone Axis
title_fullStr FSH and TSH in the Regulation of Bone Mass: The Pituitary/Immune/Bone Axis
title_full_unstemmed FSH and TSH in the Regulation of Bone Mass: The Pituitary/Immune/Bone Axis
title_short FSH and TSH in the Regulation of Bone Mass: The Pituitary/Immune/Bone Axis
title_sort fsh and tsh in the regulation of bone mass: the pituitary/immune/bone axis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683445/
https://www.ncbi.nlm.nih.gov/pubmed/23818914
http://dx.doi.org/10.1155/2013/382698
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