Cargando…
Curbing Inflammation in the Ischemic Heart Disease
A modern concept considers acute coronary syndrome as an autoinflammatory disorder. From the onset to the healing stage, an endless inflammation has been presented with complex, multiple cross-talk mechanisms at the molecular, cellular, and organ levels. Inflammatory response following acute myocard...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683484/ https://www.ncbi.nlm.nih.gov/pubmed/23819098 http://dx.doi.org/10.1155/2013/183061 |
_version_ | 1782273503511183360 |
---|---|
author | Evora, Paulo Roberto B. Nather, Julio Tubino, Paulo Victor Albuquerque, Agnes Afrodite S. Celotto, Andrea Carla Rodrigues, Alfredo J. |
author_facet | Evora, Paulo Roberto B. Nather, Julio Tubino, Paulo Victor Albuquerque, Agnes Afrodite S. Celotto, Andrea Carla Rodrigues, Alfredo J. |
author_sort | Evora, Paulo Roberto B. |
collection | PubMed |
description | A modern concept considers acute coronary syndrome as an autoinflammatory disorder. From the onset to the healing stage, an endless inflammation has been presented with complex, multiple cross-talk mechanisms at the molecular, cellular, and organ levels. Inflammatory response following acute myocardial infarction has been well documented since the 1940s and 1950s, including increased erythrocyte sedimentation rate, the C-reactive protein analysis, and the determination of serum complement. It is surprising to note, based on a wide literature overview including the following 30 years (decades of 1960, 1970, and 1980), that the inflammatory acute myocardium infarction lost its focus, virtually disappearing from the literature reports. The reversal of this historical process occurs in the 1990s with the explosion of studies involving cytokines. Considering the importance of inflammation in the pathophysiology of ischemic heart disease, the aim of this paper is to present a conceptual overview in order to explore the possibility of curbing this inflammatory process. |
format | Online Article Text |
id | pubmed-3683484 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-36834842013-07-01 Curbing Inflammation in the Ischemic Heart Disease Evora, Paulo Roberto B. Nather, Julio Tubino, Paulo Victor Albuquerque, Agnes Afrodite S. Celotto, Andrea Carla Rodrigues, Alfredo J. Int J Inflam Review Article A modern concept considers acute coronary syndrome as an autoinflammatory disorder. From the onset to the healing stage, an endless inflammation has been presented with complex, multiple cross-talk mechanisms at the molecular, cellular, and organ levels. Inflammatory response following acute myocardial infarction has been well documented since the 1940s and 1950s, including increased erythrocyte sedimentation rate, the C-reactive protein analysis, and the determination of serum complement. It is surprising to note, based on a wide literature overview including the following 30 years (decades of 1960, 1970, and 1980), that the inflammatory acute myocardium infarction lost its focus, virtually disappearing from the literature reports. The reversal of this historical process occurs in the 1990s with the explosion of studies involving cytokines. Considering the importance of inflammation in the pathophysiology of ischemic heart disease, the aim of this paper is to present a conceptual overview in order to explore the possibility of curbing this inflammatory process. Hindawi Publishing Corporation 2013 2013-05-30 /pmc/articles/PMC3683484/ /pubmed/23819098 http://dx.doi.org/10.1155/2013/183061 Text en Copyright © 2013 Paulo Roberto B. Evora et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Evora, Paulo Roberto B. Nather, Julio Tubino, Paulo Victor Albuquerque, Agnes Afrodite S. Celotto, Andrea Carla Rodrigues, Alfredo J. Curbing Inflammation in the Ischemic Heart Disease |
title | Curbing Inflammation in the Ischemic Heart Disease |
title_full | Curbing Inflammation in the Ischemic Heart Disease |
title_fullStr | Curbing Inflammation in the Ischemic Heart Disease |
title_full_unstemmed | Curbing Inflammation in the Ischemic Heart Disease |
title_short | Curbing Inflammation in the Ischemic Heart Disease |
title_sort | curbing inflammation in the ischemic heart disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683484/ https://www.ncbi.nlm.nih.gov/pubmed/23819098 http://dx.doi.org/10.1155/2013/183061 |
work_keys_str_mv | AT evorapaulorobertob curbinginflammationintheischemicheartdisease AT natherjulio curbinginflammationintheischemicheartdisease AT tubinopaulovictor curbinginflammationintheischemicheartdisease AT albuquerqueagnesafrodites curbinginflammationintheischemicheartdisease AT celottoandreacarla curbinginflammationintheischemicheartdisease AT rodriguesalfredoj curbinginflammationintheischemicheartdisease |