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Curbing Inflammation in the Ischemic Heart Disease

A modern concept considers acute coronary syndrome as an autoinflammatory disorder. From the onset to the healing stage, an endless inflammation has been presented with complex, multiple cross-talk mechanisms at the molecular, cellular, and organ levels. Inflammatory response following acute myocard...

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Detalles Bibliográficos
Autores principales: Evora, Paulo Roberto B., Nather, Julio, Tubino, Paulo Victor, Albuquerque, Agnes Afrodite S., Celotto, Andrea Carla, Rodrigues, Alfredo J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683484/
https://www.ncbi.nlm.nih.gov/pubmed/23819098
http://dx.doi.org/10.1155/2013/183061
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author Evora, Paulo Roberto B.
Nather, Julio
Tubino, Paulo Victor
Albuquerque, Agnes Afrodite S.
Celotto, Andrea Carla
Rodrigues, Alfredo J.
author_facet Evora, Paulo Roberto B.
Nather, Julio
Tubino, Paulo Victor
Albuquerque, Agnes Afrodite S.
Celotto, Andrea Carla
Rodrigues, Alfredo J.
author_sort Evora, Paulo Roberto B.
collection PubMed
description A modern concept considers acute coronary syndrome as an autoinflammatory disorder. From the onset to the healing stage, an endless inflammation has been presented with complex, multiple cross-talk mechanisms at the molecular, cellular, and organ levels. Inflammatory response following acute myocardial infarction has been well documented since the 1940s and 1950s, including increased erythrocyte sedimentation rate, the C-reactive protein analysis, and the determination of serum complement. It is surprising to note, based on a wide literature overview including the following 30 years (decades of 1960, 1970, and 1980), that the inflammatory acute myocardium infarction lost its focus, virtually disappearing from the literature reports. The reversal of this historical process occurs in the 1990s with the explosion of studies involving cytokines. Considering the importance of inflammation in the pathophysiology of ischemic heart disease, the aim of this paper is to present a conceptual overview in order to explore the possibility of curbing this inflammatory process.
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spelling pubmed-36834842013-07-01 Curbing Inflammation in the Ischemic Heart Disease Evora, Paulo Roberto B. Nather, Julio Tubino, Paulo Victor Albuquerque, Agnes Afrodite S. Celotto, Andrea Carla Rodrigues, Alfredo J. Int J Inflam Review Article A modern concept considers acute coronary syndrome as an autoinflammatory disorder. From the onset to the healing stage, an endless inflammation has been presented with complex, multiple cross-talk mechanisms at the molecular, cellular, and organ levels. Inflammatory response following acute myocardial infarction has been well documented since the 1940s and 1950s, including increased erythrocyte sedimentation rate, the C-reactive protein analysis, and the determination of serum complement. It is surprising to note, based on a wide literature overview including the following 30 years (decades of 1960, 1970, and 1980), that the inflammatory acute myocardium infarction lost its focus, virtually disappearing from the literature reports. The reversal of this historical process occurs in the 1990s with the explosion of studies involving cytokines. Considering the importance of inflammation in the pathophysiology of ischemic heart disease, the aim of this paper is to present a conceptual overview in order to explore the possibility of curbing this inflammatory process. Hindawi Publishing Corporation 2013 2013-05-30 /pmc/articles/PMC3683484/ /pubmed/23819098 http://dx.doi.org/10.1155/2013/183061 Text en Copyright © 2013 Paulo Roberto B. Evora et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Evora, Paulo Roberto B.
Nather, Julio
Tubino, Paulo Victor
Albuquerque, Agnes Afrodite S.
Celotto, Andrea Carla
Rodrigues, Alfredo J.
Curbing Inflammation in the Ischemic Heart Disease
title Curbing Inflammation in the Ischemic Heart Disease
title_full Curbing Inflammation in the Ischemic Heart Disease
title_fullStr Curbing Inflammation in the Ischemic Heart Disease
title_full_unstemmed Curbing Inflammation in the Ischemic Heart Disease
title_short Curbing Inflammation in the Ischemic Heart Disease
title_sort curbing inflammation in the ischemic heart disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683484/
https://www.ncbi.nlm.nih.gov/pubmed/23819098
http://dx.doi.org/10.1155/2013/183061
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