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Cardiovascular disease in children in Djibouti: a single-centre study

INTRODUCTION: Few data are available about pediatric cardiovascular disease (CVD) in the Horn of Africa. The objective of this study was to describe the spectrum of CVD in children in Djibouti. METHODS: Clinical features and management of Djiboutian children between 1 month-old and 15 year-old with...

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Autores principales: Massoure, Pierre-Laurent, Roche, Nicolas-Charles, Lamblin, Gatien, Dehan, Celine, Kaiser, Eric, Fourcade, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The African Field Epidemiology Network 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683514/
https://www.ncbi.nlm.nih.gov/pubmed/23785546
http://dx.doi.org/10.11604/pamj.2013.14.141.2016
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author Massoure, Pierre-Laurent
Roche, Nicolas-Charles
Lamblin, Gatien
Dehan, Celine
Kaiser, Eric
Fourcade, Laurent
author_facet Massoure, Pierre-Laurent
Roche, Nicolas-Charles
Lamblin, Gatien
Dehan, Celine
Kaiser, Eric
Fourcade, Laurent
author_sort Massoure, Pierre-Laurent
collection PubMed
description INTRODUCTION: Few data are available about pediatric cardiovascular disease (CVD) in the Horn of Africa. The objective of this study was to describe the spectrum of CVD in children in Djibouti. METHODS: Clinical features and management of Djiboutian children between 1 month-old and 15 year-old with CVD were prospectively recorded over a two-year period in Bouffard Military Hospital in Djibouti (January 2009- December 2010). RESULTS: Clinical examination and echocardiography were performed on 156 patients: 32 of them (20%) had CVD. Three (10%) of them had Down's syndrome. The median age was 5 years (male 53%). Congenital heart disease was observed in 27 (84%) patients and dilated cardiomyopathy (DCM) in 5 (16%) patients including 2 patients with rheumatic valvular disease. Ventricular septal defect was frequent (28%). Other abnormalities were atrial septal defect (13%), Tetralogy of Fallot (9%), pulmonary stenosis (6%) and 3 other patients had multiple congenital anomalies condition. Surgical management was required in 22 (69%) patients and was performed on 15 (47%) cases. During follow up (mean 11.3 ± 6.8 months), 5 (16%) patients died. Absence of surgery was associated with significant mortality (p > 0.05) but age, sex and mean follow up were not. CONCLUSION: Pediatric CVD is at least as common in this Djiboutian community as in other African cohorts. The absence of surgery was a major mortality risk factor. DCM was frequent in this study. Much work remains to be done to discover the size and nature of genetic and environmental contributions to these various forms of heart diseases in the Horn of Africa.
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spelling pubmed-36835142013-06-19 Cardiovascular disease in children in Djibouti: a single-centre study Massoure, Pierre-Laurent Roche, Nicolas-Charles Lamblin, Gatien Dehan, Celine Kaiser, Eric Fourcade, Laurent Pan Afr Med J Research INTRODUCTION: Few data are available about pediatric cardiovascular disease (CVD) in the Horn of Africa. The objective of this study was to describe the spectrum of CVD in children in Djibouti. METHODS: Clinical features and management of Djiboutian children between 1 month-old and 15 year-old with CVD were prospectively recorded over a two-year period in Bouffard Military Hospital in Djibouti (January 2009- December 2010). RESULTS: Clinical examination and echocardiography were performed on 156 patients: 32 of them (20%) had CVD. Three (10%) of them had Down's syndrome. The median age was 5 years (male 53%). Congenital heart disease was observed in 27 (84%) patients and dilated cardiomyopathy (DCM) in 5 (16%) patients including 2 patients with rheumatic valvular disease. Ventricular septal defect was frequent (28%). Other abnormalities were atrial septal defect (13%), Tetralogy of Fallot (9%), pulmonary stenosis (6%) and 3 other patients had multiple congenital anomalies condition. Surgical management was required in 22 (69%) patients and was performed on 15 (47%) cases. During follow up (mean 11.3 ± 6.8 months), 5 (16%) patients died. Absence of surgery was associated with significant mortality (p > 0.05) but age, sex and mean follow up were not. CONCLUSION: Pediatric CVD is at least as common in this Djiboutian community as in other African cohorts. The absence of surgery was a major mortality risk factor. DCM was frequent in this study. Much work remains to be done to discover the size and nature of genetic and environmental contributions to these various forms of heart diseases in the Horn of Africa. The African Field Epidemiology Network 2013-04-09 /pmc/articles/PMC3683514/ /pubmed/23785546 http://dx.doi.org/10.11604/pamj.2013.14.141.2016 Text en © Pierre-Laurent Massoure et al. http://creativecommons.org/licenses/by/2.0/ The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Massoure, Pierre-Laurent
Roche, Nicolas-Charles
Lamblin, Gatien
Dehan, Celine
Kaiser, Eric
Fourcade, Laurent
Cardiovascular disease in children in Djibouti: a single-centre study
title Cardiovascular disease in children in Djibouti: a single-centre study
title_full Cardiovascular disease in children in Djibouti: a single-centre study
title_fullStr Cardiovascular disease in children in Djibouti: a single-centre study
title_full_unstemmed Cardiovascular disease in children in Djibouti: a single-centre study
title_short Cardiovascular disease in children in Djibouti: a single-centre study
title_sort cardiovascular disease in children in djibouti: a single-centre study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683514/
https://www.ncbi.nlm.nih.gov/pubmed/23785546
http://dx.doi.org/10.11604/pamj.2013.14.141.2016
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