Cargando…

IMP-3 expression in keratoacanthomas and squamous cell carcinomas of the skin: an immunohistochemical study

The protein insulin-like growth factor II mRNA binding protein 3 (IMP-3) is an important factor for cell migration and adhesion in malignancies. Recent studies have shown a remarkable overexpression of IMP-3 in different human malignant neoplasms and also revealed it as an important prognostic marke...

Descripción completa

Detalles Bibliográficos
Autores principales: Soddu, S., Di Felice, E., Cabras, S., Castellanos, M.E., Atzori, L., Faa, G., Pilloni, L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683613/
https://www.ncbi.nlm.nih.gov/pubmed/23549465
http://dx.doi.org/10.4081/ejh.2013.e6
_version_ 1782273516927713280
author Soddu, S.
Di Felice, E.
Cabras, S.
Castellanos, M.E.
Atzori, L.
Faa, G.
Pilloni, L.
author_facet Soddu, S.
Di Felice, E.
Cabras, S.
Castellanos, M.E.
Atzori, L.
Faa, G.
Pilloni, L.
author_sort Soddu, S.
collection PubMed
description The protein insulin-like growth factor II mRNA binding protein 3 (IMP-3) is an important factor for cell migration and adhesion in malignancies. Recent studies have shown a remarkable overexpression of IMP-3 in different human malignant neoplasms and also revealed it as an important prognostic marker in some tumor entities. The purpose of this study is to compare IMP-3 immunostaining in cutaneous squamous cell tumors and determine whether IMP-3 can aid in the differential diagnosis of these lesions. To our knowledge, IMP-3 expression has not been investigated in skin squamous cell proliferations thus far. Immunohi-stochemical staining for IMP-3 was performed on slides organized by samples from 67 patients, 34 with keratoacanthoma (KA) and 33 with primary cutaneous squamous cell carcinoma (SCC) (16 invasive and 17 in situ). Seventyfour percent of KAs (25/34) were negative for IMP-3 staining, while 57% of SCCs (19/33) were positive for IMP-3 staining. The percentage of IMP-3 positive cells increased significantly in the invasive SCC group (P=0.0111), and particularly in the SCC in situ group (P=0.0021) with respect to the KA group. IMP-3 intensity staining was significantly higher in invasive SCCs (P=0.0213), and particularly in SCCs in situ (P=0.008) with respect to KA. Our data show that IMP-3 expression is different in keratoacanthoma with respect to squamous cell carcinoma. IMP-3 assessment and staining pattern, together with a careful histological study, can be useful in the differential diagnosis between KA e SCC.
format Online
Article
Text
id pubmed-3683613
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher PAGEPress Publications
record_format MEDLINE/PubMed
spelling pubmed-36836132013-06-17 IMP-3 expression in keratoacanthomas and squamous cell carcinomas of the skin: an immunohistochemical study Soddu, S. Di Felice, E. Cabras, S. Castellanos, M.E. Atzori, L. Faa, G. Pilloni, L. Eur J Histochem Original Paper The protein insulin-like growth factor II mRNA binding protein 3 (IMP-3) is an important factor for cell migration and adhesion in malignancies. Recent studies have shown a remarkable overexpression of IMP-3 in different human malignant neoplasms and also revealed it as an important prognostic marker in some tumor entities. The purpose of this study is to compare IMP-3 immunostaining in cutaneous squamous cell tumors and determine whether IMP-3 can aid in the differential diagnosis of these lesions. To our knowledge, IMP-3 expression has not been investigated in skin squamous cell proliferations thus far. Immunohi-stochemical staining for IMP-3 was performed on slides organized by samples from 67 patients, 34 with keratoacanthoma (KA) and 33 with primary cutaneous squamous cell carcinoma (SCC) (16 invasive and 17 in situ). Seventyfour percent of KAs (25/34) were negative for IMP-3 staining, while 57% of SCCs (19/33) were positive for IMP-3 staining. The percentage of IMP-3 positive cells increased significantly in the invasive SCC group (P=0.0111), and particularly in the SCC in situ group (P=0.0021) with respect to the KA group. IMP-3 intensity staining was significantly higher in invasive SCCs (P=0.0213), and particularly in SCCs in situ (P=0.008) with respect to KA. Our data show that IMP-3 expression is different in keratoacanthoma with respect to squamous cell carcinoma. IMP-3 assessment and staining pattern, together with a careful histological study, can be useful in the differential diagnosis between KA e SCC. PAGEPress Publications 2013-02-14 /pmc/articles/PMC3683613/ /pubmed/23549465 http://dx.doi.org/10.4081/ejh.2013.e6 Text en ©Copyright S. Soddu et al., 2013 This work is licensed under a Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0). Licensee PAGEPress, Italy
spellingShingle Original Paper
Soddu, S.
Di Felice, E.
Cabras, S.
Castellanos, M.E.
Atzori, L.
Faa, G.
Pilloni, L.
IMP-3 expression in keratoacanthomas and squamous cell carcinomas of the skin: an immunohistochemical study
title IMP-3 expression in keratoacanthomas and squamous cell carcinomas of the skin: an immunohistochemical study
title_full IMP-3 expression in keratoacanthomas and squamous cell carcinomas of the skin: an immunohistochemical study
title_fullStr IMP-3 expression in keratoacanthomas and squamous cell carcinomas of the skin: an immunohistochemical study
title_full_unstemmed IMP-3 expression in keratoacanthomas and squamous cell carcinomas of the skin: an immunohistochemical study
title_short IMP-3 expression in keratoacanthomas and squamous cell carcinomas of the skin: an immunohistochemical study
title_sort imp-3 expression in keratoacanthomas and squamous cell carcinomas of the skin: an immunohistochemical study
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683613/
https://www.ncbi.nlm.nih.gov/pubmed/23549465
http://dx.doi.org/10.4081/ejh.2013.e6
work_keys_str_mv AT soddus imp3expressioninkeratoacanthomasandsquamouscellcarcinomasoftheskinanimmunohistochemicalstudy
AT difelicee imp3expressioninkeratoacanthomasandsquamouscellcarcinomasoftheskinanimmunohistochemicalstudy
AT cabrass imp3expressioninkeratoacanthomasandsquamouscellcarcinomasoftheskinanimmunohistochemicalstudy
AT castellanosme imp3expressioninkeratoacanthomasandsquamouscellcarcinomasoftheskinanimmunohistochemicalstudy
AT atzoril imp3expressioninkeratoacanthomasandsquamouscellcarcinomasoftheskinanimmunohistochemicalstudy
AT faag imp3expressioninkeratoacanthomasandsquamouscellcarcinomasoftheskinanimmunohistochemicalstudy
AT pillonil imp3expressioninkeratoacanthomasandsquamouscellcarcinomasoftheskinanimmunohistochemicalstudy