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IMP-3 expression in keratoacanthomas and squamous cell carcinomas of the skin: an immunohistochemical study
The protein insulin-like growth factor II mRNA binding protein 3 (IMP-3) is an important factor for cell migration and adhesion in malignancies. Recent studies have shown a remarkable overexpression of IMP-3 in different human malignant neoplasms and also revealed it as an important prognostic marke...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PAGEPress Publications
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683613/ https://www.ncbi.nlm.nih.gov/pubmed/23549465 http://dx.doi.org/10.4081/ejh.2013.e6 |
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author | Soddu, S. Di Felice, E. Cabras, S. Castellanos, M.E. Atzori, L. Faa, G. Pilloni, L. |
author_facet | Soddu, S. Di Felice, E. Cabras, S. Castellanos, M.E. Atzori, L. Faa, G. Pilloni, L. |
author_sort | Soddu, S. |
collection | PubMed |
description | The protein insulin-like growth factor II mRNA binding protein 3 (IMP-3) is an important factor for cell migration and adhesion in malignancies. Recent studies have shown a remarkable overexpression of IMP-3 in different human malignant neoplasms and also revealed it as an important prognostic marker in some tumor entities. The purpose of this study is to compare IMP-3 immunostaining in cutaneous squamous cell tumors and determine whether IMP-3 can aid in the differential diagnosis of these lesions. To our knowledge, IMP-3 expression has not been investigated in skin squamous cell proliferations thus far. Immunohi-stochemical staining for IMP-3 was performed on slides organized by samples from 67 patients, 34 with keratoacanthoma (KA) and 33 with primary cutaneous squamous cell carcinoma (SCC) (16 invasive and 17 in situ). Seventyfour percent of KAs (25/34) were negative for IMP-3 staining, while 57% of SCCs (19/33) were positive for IMP-3 staining. The percentage of IMP-3 positive cells increased significantly in the invasive SCC group (P=0.0111), and particularly in the SCC in situ group (P=0.0021) with respect to the KA group. IMP-3 intensity staining was significantly higher in invasive SCCs (P=0.0213), and particularly in SCCs in situ (P=0.008) with respect to KA. Our data show that IMP-3 expression is different in keratoacanthoma with respect to squamous cell carcinoma. IMP-3 assessment and staining pattern, together with a careful histological study, can be useful in the differential diagnosis between KA e SCC. |
format | Online Article Text |
id | pubmed-3683613 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | PAGEPress Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-36836132013-06-17 IMP-3 expression in keratoacanthomas and squamous cell carcinomas of the skin: an immunohistochemical study Soddu, S. Di Felice, E. Cabras, S. Castellanos, M.E. Atzori, L. Faa, G. Pilloni, L. Eur J Histochem Original Paper The protein insulin-like growth factor II mRNA binding protein 3 (IMP-3) is an important factor for cell migration and adhesion in malignancies. Recent studies have shown a remarkable overexpression of IMP-3 in different human malignant neoplasms and also revealed it as an important prognostic marker in some tumor entities. The purpose of this study is to compare IMP-3 immunostaining in cutaneous squamous cell tumors and determine whether IMP-3 can aid in the differential diagnosis of these lesions. To our knowledge, IMP-3 expression has not been investigated in skin squamous cell proliferations thus far. Immunohi-stochemical staining for IMP-3 was performed on slides organized by samples from 67 patients, 34 with keratoacanthoma (KA) and 33 with primary cutaneous squamous cell carcinoma (SCC) (16 invasive and 17 in situ). Seventyfour percent of KAs (25/34) were negative for IMP-3 staining, while 57% of SCCs (19/33) were positive for IMP-3 staining. The percentage of IMP-3 positive cells increased significantly in the invasive SCC group (P=0.0111), and particularly in the SCC in situ group (P=0.0021) with respect to the KA group. IMP-3 intensity staining was significantly higher in invasive SCCs (P=0.0213), and particularly in SCCs in situ (P=0.008) with respect to KA. Our data show that IMP-3 expression is different in keratoacanthoma with respect to squamous cell carcinoma. IMP-3 assessment and staining pattern, together with a careful histological study, can be useful in the differential diagnosis between KA e SCC. PAGEPress Publications 2013-02-14 /pmc/articles/PMC3683613/ /pubmed/23549465 http://dx.doi.org/10.4081/ejh.2013.e6 Text en ©Copyright S. Soddu et al., 2013 This work is licensed under a Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0). Licensee PAGEPress, Italy |
spellingShingle | Original Paper Soddu, S. Di Felice, E. Cabras, S. Castellanos, M.E. Atzori, L. Faa, G. Pilloni, L. IMP-3 expression in keratoacanthomas and squamous cell carcinomas of the skin: an immunohistochemical study |
title | IMP-3 expression in keratoacanthomas and squamous cell carcinomas of the skin: an immunohistochemical study |
title_full | IMP-3 expression in keratoacanthomas and squamous cell carcinomas of the skin: an immunohistochemical study |
title_fullStr | IMP-3 expression in keratoacanthomas and squamous cell carcinomas of the skin: an immunohistochemical study |
title_full_unstemmed | IMP-3 expression in keratoacanthomas and squamous cell carcinomas of the skin: an immunohistochemical study |
title_short | IMP-3 expression in keratoacanthomas and squamous cell carcinomas of the skin: an immunohistochemical study |
title_sort | imp-3 expression in keratoacanthomas and squamous cell carcinomas of the skin: an immunohistochemical study |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683613/ https://www.ncbi.nlm.nih.gov/pubmed/23549465 http://dx.doi.org/10.4081/ejh.2013.e6 |
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