The Involvement of Cholinergic Neurons in the Spreading of Tau Pathology

Long time ago, it was described the selective loss of cholinergic neurons during the development of Alzheimer disease (AD). Recently, it has been suggested that tau protein may play a role in that loss of cholinergic neurons through a mechanism involving the interaction of extracellular tau with M1/...

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Autores principales: Simón, Diana, Hernández, Félix, Avila, Jesús
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683623/
https://www.ncbi.nlm.nih.gov/pubmed/23785352
http://dx.doi.org/10.3389/fneur.2013.00074
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author Simón, Diana
Hernández, Félix
Avila, Jesús
author_facet Simón, Diana
Hernández, Félix
Avila, Jesús
author_sort Simón, Diana
collection PubMed
description Long time ago, it was described the selective loss of cholinergic neurons during the development of Alzheimer disease (AD). Recently, it has been suggested that tau protein may play a role in that loss of cholinergic neurons through a mechanism involving the interaction of extracellular tau with M1/M3 muscarinic receptors present in the cholinergic neurons. This interaction between tau and muscarinic receptors may be a way, although not the only one, to explain the spreading of tau pathology occurring in AD.
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spelling pubmed-36836232013-06-19 The Involvement of Cholinergic Neurons in the Spreading of Tau Pathology Simón, Diana Hernández, Félix Avila, Jesús Front Neurol Neuroscience Long time ago, it was described the selective loss of cholinergic neurons during the development of Alzheimer disease (AD). Recently, it has been suggested that tau protein may play a role in that loss of cholinergic neurons through a mechanism involving the interaction of extracellular tau with M1/M3 muscarinic receptors present in the cholinergic neurons. This interaction between tau and muscarinic receptors may be a way, although not the only one, to explain the spreading of tau pathology occurring in AD. Frontiers Media S.A. 2013-06-17 /pmc/articles/PMC3683623/ /pubmed/23785352 http://dx.doi.org/10.3389/fneur.2013.00074 Text en Copyright © 2013 Simón, Hernández and Avila. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Neuroscience
Simón, Diana
Hernández, Félix
Avila, Jesús
The Involvement of Cholinergic Neurons in the Spreading of Tau Pathology
title The Involvement of Cholinergic Neurons in the Spreading of Tau Pathology
title_full The Involvement of Cholinergic Neurons in the Spreading of Tau Pathology
title_fullStr The Involvement of Cholinergic Neurons in the Spreading of Tau Pathology
title_full_unstemmed The Involvement of Cholinergic Neurons in the Spreading of Tau Pathology
title_short The Involvement of Cholinergic Neurons in the Spreading of Tau Pathology
title_sort involvement of cholinergic neurons in the spreading of tau pathology
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683623/
https://www.ncbi.nlm.nih.gov/pubmed/23785352
http://dx.doi.org/10.3389/fneur.2013.00074
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