Hsp90 facilitates accurate loading of precursor piRNAs into PIWI proteins

PIWI-interacting RNAs (piRNAs) defend the genome against transposon activity in animal gonads. The Hsp90 chaperone machinery has been implicated in the piRNA pathway, but its exact role remains obscure. Here, we examined the effect of 17-N-allylamino-17-demethoxygeldanamycin (17-AAG), an Hsp90-speci...

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Detalles Bibliográficos
Autores principales: Izumi, Natsuko, Kawaoka, Shinpei, Yasuhara, Satoshi, Suzuki, Yutaka, Sugano, Sumio, Katsuma, Susumu, Tomari, Yukihide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2013
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683924/
https://www.ncbi.nlm.nih.gov/pubmed/23681506
http://dx.doi.org/10.1261/rna.037200.112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683924/
https://www.ncbi.nlm.nih.gov/pubmed/23681506
http://dx.doi.org/10.1261/rna.037200.112

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