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A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

Despite the considerable progress made in the stent development in the last decades, cardiovascular diseases remain the main cause of death in western countries. Beside the benefits offered by the development of different drug-eluting stents, the coronary revascularization bears also the life-threat...

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Autores principales: Simsekyilmaz, Sakine, Schreiber, Fabian, Weinandy, Stefan, Gremse, Felix, Sönmez, Tolga Taha, Liehn, Elisa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MyJove Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683934/
https://www.ncbi.nlm.nih.gov/pubmed/23711999
http://dx.doi.org/10.3791/50233
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author Simsekyilmaz, Sakine
Schreiber, Fabian
Weinandy, Stefan
Gremse, Felix
Sönmez, Tolga Taha
Liehn, Elisa A.
author_facet Simsekyilmaz, Sakine
Schreiber, Fabian
Weinandy, Stefan
Gremse, Felix
Sönmez, Tolga Taha
Liehn, Elisa A.
author_sort Simsekyilmaz, Sakine
collection PubMed
description Despite the considerable progress made in the stent development in the last decades, cardiovascular diseases remain the main cause of death in western countries. Beside the benefits offered by the development of different drug-eluting stents, the coronary revascularization bears also the life-threatening risks of in-stent thrombosis and restenosis. Research on new therapeutic strategies is impaired by the lack of appropriate methods to study stent implantation and restenosis processes. Here, we describe a rapid and accessible procedure of stent implantation in mouse carotid artery, which offers the possibility to study in a convenient way the molecular mechanisms of vessel remodeling and the effects of different drug coatings.
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spelling pubmed-36839342013-06-19 A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis Simsekyilmaz, Sakine Schreiber, Fabian Weinandy, Stefan Gremse, Felix Sönmez, Tolga Taha Liehn, Elisa A. J Vis Exp Medicine Despite the considerable progress made in the stent development in the last decades, cardiovascular diseases remain the main cause of death in western countries. Beside the benefits offered by the development of different drug-eluting stents, the coronary revascularization bears also the life-threatening risks of in-stent thrombosis and restenosis. Research on new therapeutic strategies is impaired by the lack of appropriate methods to study stent implantation and restenosis processes. Here, we describe a rapid and accessible procedure of stent implantation in mouse carotid artery, which offers the possibility to study in a convenient way the molecular mechanisms of vessel remodeling and the effects of different drug coatings. MyJove Corporation 2013-05-14 /pmc/articles/PMC3683934/ /pubmed/23711999 http://dx.doi.org/10.3791/50233 Text en Copyright © 2013, Journal of Visualized Experiments http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visithttp://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Medicine
Simsekyilmaz, Sakine
Schreiber, Fabian
Weinandy, Stefan
Gremse, Felix
Sönmez, Tolga Taha
Liehn, Elisa A.
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
title A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
title_full A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
title_fullStr A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
title_full_unstemmed A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
title_short A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
title_sort murine model of stent implantation in the carotid artery for the study of restenosis
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683934/
https://www.ncbi.nlm.nih.gov/pubmed/23711999
http://dx.doi.org/10.3791/50233
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