Cargando…

Decursin and Doxorubicin Are in Synergy for the Induction of Apoptosis via STAT3 and/or mTOR Pathways in Human Multiple Myeloma Cells

Background. Combination cancer therapy is one of the attractive approaches to overcome drug resistance of cancer cells. In the present study, we investigated the synergistic effect of decursin from Angelica gigas and doxorubicin on the induction of apoptosis in three human multiple myeloma cells. Me...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jang, Jinsil, Jeong, Soo-Jin, Kwon, Hee-Young, Jung, Ji Hoon, Sohn, Eun Jung, Lee, Hyo-Jung, Kim, Ji-Hyun, Kim, Sun-Hee, Kim, Jin Hyoung, Kim, Sung-Hoon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684033/ https://www.ncbi.nlm.nih.gov/pubmed/23818927 http://dx.doi.org/10.1155/2013/506324

Ejemplares similares

Inhibition of STAT3 signaling and induction of SHP1 mediate antiangiogenic and antitumor activities of ergosterol peroxide in U266 multiple myeloma cells
por: Rhee, Yun-Hee, et al.
Publicado: (2012)

Decursin and decursinol angelate inhibit estrogen-stimulated and estrogen-independent growth and survival of breast cancer cells
por: Jiang, Cheng, et al.
Publicado: (2007)

Decursin inhibits retinal neovascularization via suppression of VEGFR-2 activation
por: Kim, Jeong Hun, et al.
Publicado: (2009)

mTOR-Mediated Antioxidant Activation in Solid Tumor Radioresistance
por: Woo, Yunseo, et al.
Publicado: (2019)

Decursin inhibits tumor progression in head and neck squamous cell carcinoma by downregulating CXCR7 expression in vitro
por: Joo, Mina, et al.
Publicado: (2022)

Icariside II Induces Apoptosis in U937 Acute Myeloid Leukemia Cells: Role of Inactivation of STAT3-Related Signaling
por: Kang, Sang-Hun, et al.
Publicado: (2012)

Decursin and Decursinol Angelate Suppress Adipogenesis through Activation of β-catenin Signaling Pathway in Human Visceral Adipose-Derived Stem Cells
por: Park, In Sil, et al.
Publicado: (2019)

Kahweol Induces Apoptosis in Hepatocellular Carcinoma Cells by Inhibiting the Src/mTOR/STAT3 Signaling Pathway
por: Seo, Hye-Young, et al.
Publicado: (2021)

Protective Effect of Decursin Extracted from Angelica gigas in Male Infertility via Nrf2/HO-1 Signaling Pathway
por: Bae, Woong Jin, et al.
Publicado: (2016)

Decursin Alleviates Mechanical Allodynia in a Paclitaxel-Induced Neuropathic Pain Mouse Model
por: Son, Dang Bao, et al.
Publicado: (2021)

Apoptosis Induced by Tanshinone IIA and Cryptotanshinone Is Mediated by Distinct JAK/STAT3/5 and SHP1/2 Signaling in Chronic Myeloid Leukemia K562 Cells
por: Jung, Ji Hoon, et al.
Publicado: (2013)

Corrigendum to “Apoptosis Induced by Tanshinone IIA and Cryptotanshinone Is Mediated by Distinct JAK/STAT3/5 and SHP1/2 Signaling in Chronic Myeloid Leukemia K562 Cells”
por: Jung, Ji Hoon, et al.
Publicado: (2018)

Involvement of mTOR signaling in sphingosylphosphorylcholine-induced hypopigmentation effects
por: Jeong, Hyo-Soon, et al.
Publicado: (2011)

Effect of Angelica gigas Nakai Ethanol Extract and Decursin on Human Pancreatic Cancer Cells
por: Kweon, Bitna, et al.
Publicado: (2020)

Inhibitory Effect of mTOR Activator MHY1485 on Autophagy: Suppression of Lysosomal Fusion
por: Choi, Yeon Ja, et al.
Publicado: (2012)

Chrysin Induces Apoptosis via the MAPK Pathway and Regulates ERK/mTOR-Mediated Autophagy in MC-3 Cells
por: Jung, Gi-Hwan, et al.
Publicado: (2022)

Correction: Inhibitory Effect of mTOR Activator MHY1485 on Autophagy: Suppression of Lysosomal Fusion
por: Choi, Yeon Ja, et al.
Publicado: (2013)

Chrysin Induces Apoptosis and Autophagy in Human Melanoma Cells via the mTOR/S6K Pathway
por: Lee, Jae-Han, et al.
Publicado: (2022)

Characterization of developmental defects in the forebrain resulting from hyperactivated mTOR signaling by integrative analysis of transcriptomic and proteomic data
por: Shin, Jiheon, et al.
Publicado: (2017)

mTOR Signaling Combined with Cancer Stem Cell Markers as a Survival Predictor in Stage II Colorectal Cancer
por: Chang, Ji Young, et al.
Publicado: (2020)

Effects of Stuffer DNA on the Suppression of Choroidal Neovascularization by a rAAV Expressing a mTOR-Inhibiting shRNA
por: Lee, Steven Hyun Seung, et al.
Publicado: (2019)

Monotropein Improves Dexamethasone-Induced Muscle Atrophy via the AKT/mTOR/FOXO3a Signaling Pathways
por: Wang, Piao, et al.
Publicado: (2022)

Anti-Fibrotic Effect of Synthetic Noncoding Oligodeoxynucleotide for Inhibiting mTOR and STAT3 via the Regulation of Autophagy in an Animal Model of Renal Injury
por: Jung, Hyun Jin, et al.
Publicado: (2022)

Suppression of STAT3 Phosphorylation and RelA/p65 Acetylation Mediated by MicroRNA134 Plays a Pivotal Role in the Apoptotic Effect of Lambertianic Acid
por: Sim, Deok Yong, et al.
Publicado: (2019)

NANOG regulates epithelial–mesenchymal transition via AMPK/mTOR signalling pathway in ovarian cancer SKOV‐3 and A2780 cells
por: Yun, Hee, et al.
Publicado: (2022)

Network Pharmacology Study and Experimental Confirmation Revealing the Ameliorative Effects of Decursin on Chemotherapy-Induced Alopecia
por: Kim, Mi Hye, et al.
Publicado: (2021)

Myricetin induces apoptosis and autophagy in human gastric cancer cells through inhibition of the PI3K/Akt/mTOR pathway
por: Han, So-Hee, et al.
Publicado: (2022)

Inhibition of Connexin 26/43 and Extracellular-Regulated Kinase Protein Plays a Critical Role in Melatonin Facilitated Gap Junctional Intercellular Communication in Hydrogen Peroxide-Treated HaCaT Keratinocyte Cells
por: Lee, Hyo-Jung, et al.
Publicado: (2012)

Apoptotic Effects of Xanthium strumarium via PI3K/AKT/mTOR Pathway in Hepatocellular Carcinoma
por: Kim, Juyoung, et al.
Publicado: (2019)

PS114. Effects of Tianeptine on mTOR Signaling in Rat Hippocampal Neurons
por: Seo, Mi Kyoung, et al.
Publicado: (2016)

Validation of the revised diagnostic criteria for primary plasma cell leukemia by the Korean Multiple Myeloma Working Party
por: Jung, Sung-Hoon, et al.
Publicado: (2022)

Epigenetic downregulation of STAT6 increases HIF-1α expression via mTOR/S6K/S6, leading to enhanced hypoxic viability of glioma cells
por: Park, Soo Jung, et al.
Publicado: (2019)

Angelica gigas Nakai and Decursin Downregulate Myc Expression to Promote Cell Death in B-cell Lymphoma
por: Kim, Eungyoung, et al.
Publicado: (2018)

Thalidomide Induced Nonspecific Interstitial Pneumonia in Patient with Relapsed Multiple Myeloma
por: Kang, Myung-Hee, et al.
Publicado: (2010)

Misaponin B Induces G2/M Arrest, Cytokinesis Failure and Impairs Autophagy
por: Won, Gunho, et al.
Publicado: (2020)

Effects of Decursin and Angelica gigas Nakai Root Extract on Hair Growth in Mouse Dorsal Skin via Regulating Inflammatory Cytokines
por: Lee, Tae-Kyeong, et al.
Publicado: (2020)

A Mechanism for Synergy with Combined mTOR and PI3 Kinase Inhibitors
por: Yang, Shujie, et al.
Publicado: (2011)

Benefits of additional cycles of bortezomib/thalidomide/dexamethasone (VTD) induction therapy compared to four cycles of VTD for newly diagnosed multiple myeloma
por: Lee, Yoo Jin, et al.
Publicado: (2019)

Chronic Repression of mTOR Complex 2 Induces Changes in the Gut Microbiota of Diet-induced Obese Mice
por: Jung, Mi-Ja, et al.
Publicado: (2016)

The Impact of Hyperglycemia on Risk of Severe Infections during Early Period of Induction Therapy in Patients with Newly Diagnosed Multiple Myeloma
por: Jung, Sung-Hoon, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_8h36pm50d59n6g0smspli800st