The effects of chemotherapeutics on cellular metabolism and consequent immune recognition

A widely held view is that oncolytic agents induce death of tumor cells directly. In this report we review and discuss the apoptosis-inducing effects of chemotherapeutics, the effects of chemotherapeutics on metabolic function, and the consequent effects of metabolic function on immune recognition....

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Detalles Bibliográficos
Autores principales: Newell, M Karen, Melamede, Robert, Villalobos-Menuey, Elizabeth, Swartzendruber, Douglas, Trauger, Richard, Camley, Robert E, Crisp, William
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC368444/
https://www.ncbi.nlm.nih.gov/pubmed/14756899
http://dx.doi.org/10.1186/1476-8518-2-3
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author Newell, M Karen
Melamede, Robert
Villalobos-Menuey, Elizabeth
Swartzendruber, Douglas
Trauger, Richard
Camley, Robert E
Crisp, William
author_facet Newell, M Karen
Melamede, Robert
Villalobos-Menuey, Elizabeth
Swartzendruber, Douglas
Trauger, Richard
Camley, Robert E
Crisp, William
author_sort Newell, M Karen
collection PubMed
description A widely held view is that oncolytic agents induce death of tumor cells directly. In this report we review and discuss the apoptosis-inducing effects of chemotherapeutics, the effects of chemotherapeutics on metabolic function, and the consequent effects of metabolic function on immune recognition. Finally, we propose that effective chemotherapeutic and/or apoptosis-inducing agents, at concentrations that can be achieved physiologically, do not kill tumor cells directly. Rather, we suggest that effective oncolytic agents sensitize immunologically altered tumor cells to immune recognition and immune-directed cell death.
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spelling pubmed-3684442004-03-14 The effects of chemotherapeutics on cellular metabolism and consequent immune recognition Newell, M Karen Melamede, Robert Villalobos-Menuey, Elizabeth Swartzendruber, Douglas Trauger, Richard Camley, Robert E Crisp, William J Immune Based Ther Vaccines Review A widely held view is that oncolytic agents induce death of tumor cells directly. In this report we review and discuss the apoptosis-inducing effects of chemotherapeutics, the effects of chemotherapeutics on metabolic function, and the consequent effects of metabolic function on immune recognition. Finally, we propose that effective chemotherapeutic and/or apoptosis-inducing agents, at concentrations that can be achieved physiologically, do not kill tumor cells directly. Rather, we suggest that effective oncolytic agents sensitize immunologically altered tumor cells to immune recognition and immune-directed cell death. BioMed Central 2004-02-02 /pmc/articles/PMC368444/ /pubmed/14756899 http://dx.doi.org/10.1186/1476-8518-2-3 Text en Copyright © 2004 Newell et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
spellingShingle Review
Newell, M Karen
Melamede, Robert
Villalobos-Menuey, Elizabeth
Swartzendruber, Douglas
Trauger, Richard
Camley, Robert E
Crisp, William
The effects of chemotherapeutics on cellular metabolism and consequent immune recognition
title The effects of chemotherapeutics on cellular metabolism and consequent immune recognition
title_full The effects of chemotherapeutics on cellular metabolism and consequent immune recognition
title_fullStr The effects of chemotherapeutics on cellular metabolism and consequent immune recognition
title_full_unstemmed The effects of chemotherapeutics on cellular metabolism and consequent immune recognition
title_short The effects of chemotherapeutics on cellular metabolism and consequent immune recognition
title_sort effects of chemotherapeutics on cellular metabolism and consequent immune recognition
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC368444/
https://www.ncbi.nlm.nih.gov/pubmed/14756899
http://dx.doi.org/10.1186/1476-8518-2-3
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