WW Domain Containing E3 Ubiquitin Protein Ligase 1 (WWP1) Negatively Regulates TLR4-Mediated TNF-α and IL-6 Production by Proteasomal Degradation of TNF Receptor Associated Factor 6 (TRAF6)

BACKGROUND: Toll-like receptors (TLRs) play a pivotal role in the defense against invading pathogens by detecting pathogen-associated molecular patterns (PAMPs). TLR4 recognizes lipopolysaccharides (LPS) in the cell walls of Gram-negative bacteria, resulting in the induction and secretion of proinfl...

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Detalles Bibliográficos
Autores principales: Lin, Xiao-Wen, Xu, Wei-Cheng, Luo, Jian-Gang, Guo, Xue-Jiao, Sun, Tao, Zhao, Xu-Li, Fu, Zhi-Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684580/
https://www.ncbi.nlm.nih.gov/pubmed/23799152
http://dx.doi.org/10.1371/journal.pone.0067633

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