A Unified Proteochemometric Model for Prediction of Inhibition of Cytochrome P450 Isoforms

A unified proteochemometric (PCM) model for the prediction of the ability of drug-like chemicals to inhibit five major drug metabolizing CYP isoforms (i.e. CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4) was created and made publicly available under the Bioclipse Decision Support open source system at w...

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Detalles Bibliográficos
Autores principales: Lapins, Maris, Worachartcheewan, Apilak, Spjuth, Ola, Georgiev, Valentin, Prachayasittikul, Virapong, Nantasenamat, Chanin, Wikberg, Jarl E. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684587/
https://www.ncbi.nlm.nih.gov/pubmed/23799117
http://dx.doi.org/10.1371/journal.pone.0066566

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