CSTP1, a Novel Protein Phosphatase, Blocks Cell Cycle, Promotes Cell Apoptosis, and Suppresses Tumor Growth of Bladder Cancer by Directly Dephosphorylating Akt at Ser473 Site

Akt/protein kinase B is a pivotal component downstream of phosphatidylinositol 3-kinase (PI3K) pathway, whose activity regulates the balance between cell survival and apoptosis. Phosphorylation of Akt occurs at two key sites either at Thr308 site in the activation loop or at Ser473 site in the hydro...

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Detalles Bibliográficos
Autores principales: Zhuo, De-Xiang, Zhang, Xiao-Wei, Jin, Bo, Zhang, Zheng, Xie, Bu-Shan, Wu, Cheng-Lin, Gong, Kan, Mao, Ze-Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684612/
https://www.ncbi.nlm.nih.gov/pubmed/23799035
http://dx.doi.org/10.1371/journal.pone.0065679

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