Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization

hIAPP fibrillization implicated in Type 2 diabetes pathology involves formation of oligomers toxic to insulin producing pancreatic β-cells. We report design, synthesis, 3D structure and functional characterization of dehydrophenylalanine (ΔF) containing peptides which inhibit hIAPP fibrillization. T...

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Autores principales: Mishra, Aseem, Misra, Anurag, Sri Vaishnavi, T., Thota, Chaitanya, Gupta, Madhvi, Ramakumar, Suryanarayanarao, Chauhan, Virander Singh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2013
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684849/
https://www.ncbi.nlm.nih.gov/pubmed/23435449
http://dx.doi.org/10.1039/c3cc38982k
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author Mishra, Aseem
Misra, Anurag
Sri Vaishnavi, T.
Thota, Chaitanya
Gupta, Madhvi
Ramakumar, Suryanarayanarao
Chauhan, Virander Singh
author_facet Mishra, Aseem
Misra, Anurag
Sri Vaishnavi, T.
Thota, Chaitanya
Gupta, Madhvi
Ramakumar, Suryanarayanarao
Chauhan, Virander Singh
author_sort Mishra, Aseem
collection PubMed
description hIAPP fibrillization implicated in Type 2 diabetes pathology involves formation of oligomers toxic to insulin producing pancreatic β-cells. We report design, synthesis, 3D structure and functional characterization of dehydrophenylalanine (ΔF) containing peptides which inhibit hIAPP fibrillization. The inhibitor protects β-cells from hIAPP induced toxicity.
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spelling pubmed-36848492013-06-18 Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization Mishra, Aseem Misra, Anurag Sri Vaishnavi, T. Thota, Chaitanya Gupta, Madhvi Ramakumar, Suryanarayanarao Chauhan, Virander Singh Chem Commun (Camb) Chemistry hIAPP fibrillization implicated in Type 2 diabetes pathology involves formation of oligomers toxic to insulin producing pancreatic β-cells. We report design, synthesis, 3D structure and functional characterization of dehydrophenylalanine (ΔF) containing peptides which inhibit hIAPP fibrillization. The inhibitor protects β-cells from hIAPP induced toxicity. Royal Society of Chemistry 2013-04-04 2013-02-25 /pmc/articles/PMC3684849/ /pubmed/23435449 http://dx.doi.org/10.1039/c3cc38982k Text en This journal is © The Royal Society of Chemistry 2013 http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Mishra, Aseem
Misra, Anurag
Sri Vaishnavi, T.
Thota, Chaitanya
Gupta, Madhvi
Ramakumar, Suryanarayanarao
Chauhan, Virander Singh
Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization
title Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization
title_full Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization
title_fullStr Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization
title_full_unstemmed Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization
title_short Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization
title_sort conformationally restricted short peptides inhibit human islet amyloid polypeptide (hiapp) fibrillization
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684849/
https://www.ncbi.nlm.nih.gov/pubmed/23435449
http://dx.doi.org/10.1039/c3cc38982k
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