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Methyl (3S,10b’S)-5-chloro-9′-fluoro-1-methyl-2-oxo-5′-phenyl-10b’H-spiro[indoline-3,1′-pyrazolo[3,2-a]isoquinoline]-2′-carboxylate
In the title compound, C(27)H(19)ClFN(3)O(3), the pyrazole ring has a twist conformation and the six-membered ring to which it is fused has a screw-boat conformation. The mean plane of the pyrazole ring is inclined to the 2-methylindoline ring by 85.03 (9) and by 28.17 (8)° to the mean plane of the...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
International Union of Crystallography
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684913/ https://www.ncbi.nlm.nih.gov/pubmed/23795015 http://dx.doi.org/10.1107/S1600536813011549 |
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| author | Kannan, Piskala Subburaman Yuvaraj, PanneerSelvam Reddy, Boreddy Siva Rami Raja, Rajamani SubbiahPandi, Arunachalathevar |
| author_facet | Kannan, Piskala Subburaman Yuvaraj, PanneerSelvam Reddy, Boreddy Siva Rami Raja, Rajamani SubbiahPandi, Arunachalathevar |
| author_sort | Kannan, Piskala Subburaman |
| collection | PubMed |
| description | In the title compound, C(27)H(19)ClFN(3)O(3), the pyrazole ring has a twist conformation and the six-membered ring to which it is fused has a screw-boat conformation. The mean plane of the pyrazole ring is inclined to the 2-methylindoline ring by 85.03 (9) and by 28.17 (8)° to the mean plane of the isoquinoline ring system. In the crystal, molecules are linked by pairs of C—H⋯F hydrogen bonds, forming inversion dimers. These dimers are linked via C—H⋯O hydrogen bonds, forming a two-dimensional network lying parallel to (10-1). |
| format | Online Article Text |
| id | pubmed-3684913 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2013 |
| publisher | International Union of Crystallography |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-36849132013-06-21 Methyl (3S,10b’S)-5-chloro-9′-fluoro-1-methyl-2-oxo-5′-phenyl-10b’H-spiro[indoline-3,1′-pyrazolo[3,2-a]isoquinoline]-2′-carboxylate Kannan, Piskala Subburaman Yuvaraj, PanneerSelvam Reddy, Boreddy Siva Rami Raja, Rajamani SubbiahPandi, Arunachalathevar Acta Crystallogr Sect E Struct Rep Online Organic Papers In the title compound, C(27)H(19)ClFN(3)O(3), the pyrazole ring has a twist conformation and the six-membered ring to which it is fused has a screw-boat conformation. The mean plane of the pyrazole ring is inclined to the 2-methylindoline ring by 85.03 (9) and by 28.17 (8)° to the mean plane of the isoquinoline ring system. In the crystal, molecules are linked by pairs of C—H⋯F hydrogen bonds, forming inversion dimers. These dimers are linked via C—H⋯O hydrogen bonds, forming a two-dimensional network lying parallel to (10-1). International Union of Crystallography 2013-05-04 /pmc/articles/PMC3684913/ /pubmed/23795015 http://dx.doi.org/10.1107/S1600536813011549 Text en © Kannan et al. 2013 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
| spellingShingle | Organic Papers Kannan, Piskala Subburaman Yuvaraj, PanneerSelvam Reddy, Boreddy Siva Rami Raja, Rajamani SubbiahPandi, Arunachalathevar Methyl (3S,10b’S)-5-chloro-9′-fluoro-1-methyl-2-oxo-5′-phenyl-10b’H-spiro[indoline-3,1′-pyrazolo[3,2-a]isoquinoline]-2′-carboxylate |
| title | Methyl (3S,10b’S)-5-chloro-9′-fluoro-1-methyl-2-oxo-5′-phenyl-10b’H-spiro[indoline-3,1′-pyrazolo[3,2-a]isoquinoline]-2′-carboxylate |
| title_full | Methyl (3S,10b’S)-5-chloro-9′-fluoro-1-methyl-2-oxo-5′-phenyl-10b’H-spiro[indoline-3,1′-pyrazolo[3,2-a]isoquinoline]-2′-carboxylate |
| title_fullStr | Methyl (3S,10b’S)-5-chloro-9′-fluoro-1-methyl-2-oxo-5′-phenyl-10b’H-spiro[indoline-3,1′-pyrazolo[3,2-a]isoquinoline]-2′-carboxylate |
| title_full_unstemmed | Methyl (3S,10b’S)-5-chloro-9′-fluoro-1-methyl-2-oxo-5′-phenyl-10b’H-spiro[indoline-3,1′-pyrazolo[3,2-a]isoquinoline]-2′-carboxylate |
| title_short | Methyl (3S,10b’S)-5-chloro-9′-fluoro-1-methyl-2-oxo-5′-phenyl-10b’H-spiro[indoline-3,1′-pyrazolo[3,2-a]isoquinoline]-2′-carboxylate |
| title_sort | methyl (3s,10b’s)-5-chloro-9′-fluoro-1-methyl-2-oxo-5′-phenyl-10b’h-spiro[indoline-3,1′-pyrazolo[3,2-a]isoquinoline]-2′-carboxylate |
| topic | Organic Papers |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684913/ https://www.ncbi.nlm.nih.gov/pubmed/23795015 http://dx.doi.org/10.1107/S1600536813011549 |
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