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6′-(1,3-Diphenyl-1H-pyrazol-4-yl)-7′-(1H-indol-3-ylcarbonyl)-2-oxo-1-(prop-2-en-1-yl)-5′,6′,7′,7a’-tetrahydro-1′H-spiro[indoline-3,5′-pyrrolo[1,2-c][1,3]thiazole]-7′-carbonitrile
In the title compound, C(41)H(32)N(6)O(2)S, the pyrrolothiazole ring system is folded about the bridging N—C bond. The thiazolidine and pyrrolidine rings adopt envelope (with the fused C atom as the flap) and twisted conformations, respectively. The two phenyl rings attached to the pyrazole ring...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
International Union of Crystallography
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684939/ https://www.ncbi.nlm.nih.gov/pubmed/23795041 http://dx.doi.org/10.1107/S1600536813011513 |
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| author | Kannan, Piskala Subburaman Kathirvelan, Devaraj Reddy, Boreddy Siva Rami Govindan, Elumalai SubbiahPandi, Arunachalathevar |
| author_facet | Kannan, Piskala Subburaman Kathirvelan, Devaraj Reddy, Boreddy Siva Rami Govindan, Elumalai SubbiahPandi, Arunachalathevar |
| author_sort | Kannan, Piskala Subburaman |
| collection | PubMed |
| description | In the title compound, C(41)H(32)N(6)O(2)S, the pyrrolothiazole ring system is folded about the bridging N—C bond. The thiazolidine and pyrrolidine rings adopt envelope (with the fused C atom as the flap) and twisted conformations, respectively. The two phenyl rings attached to the pyrazole ring are twisted from the plane of the latter by 6.8 (1) and 52.8 (1)°. The allyl group is disordered over two conformations in a 0.805 (6):0.195 (6) ratio. In the crystal, pairs of N—H⋯O hydrogen bonds link the molecules into centrosymmetric dimers. |
| format | Online Article Text |
| id | pubmed-3684939 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2013 |
| publisher | International Union of Crystallography |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-36849392013-06-21 6′-(1,3-Diphenyl-1H-pyrazol-4-yl)-7′-(1H-indol-3-ylcarbonyl)-2-oxo-1-(prop-2-en-1-yl)-5′,6′,7′,7a’-tetrahydro-1′H-spiro[indoline-3,5′-pyrrolo[1,2-c][1,3]thiazole]-7′-carbonitrile Kannan, Piskala Subburaman Kathirvelan, Devaraj Reddy, Boreddy Siva Rami Govindan, Elumalai SubbiahPandi, Arunachalathevar Acta Crystallogr Sect E Struct Rep Online Organic Papers In the title compound, C(41)H(32)N(6)O(2)S, the pyrrolothiazole ring system is folded about the bridging N—C bond. The thiazolidine and pyrrolidine rings adopt envelope (with the fused C atom as the flap) and twisted conformations, respectively. The two phenyl rings attached to the pyrazole ring are twisted from the plane of the latter by 6.8 (1) and 52.8 (1)°. The allyl group is disordered over two conformations in a 0.805 (6):0.195 (6) ratio. In the crystal, pairs of N—H⋯O hydrogen bonds link the molecules into centrosymmetric dimers. International Union of Crystallography 2013-05-11 /pmc/articles/PMC3684939/ /pubmed/23795041 http://dx.doi.org/10.1107/S1600536813011513 Text en © Kannan et al. 2013 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
| spellingShingle | Organic Papers Kannan, Piskala Subburaman Kathirvelan, Devaraj Reddy, Boreddy Siva Rami Govindan, Elumalai SubbiahPandi, Arunachalathevar 6′-(1,3-Diphenyl-1H-pyrazol-4-yl)-7′-(1H-indol-3-ylcarbonyl)-2-oxo-1-(prop-2-en-1-yl)-5′,6′,7′,7a’-tetrahydro-1′H-spiro[indoline-3,5′-pyrrolo[1,2-c][1,3]thiazole]-7′-carbonitrile |
| title | 6′-(1,3-Diphenyl-1H-pyrazol-4-yl)-7′-(1H-indol-3-ylcarbonyl)-2-oxo-1-(prop-2-en-1-yl)-5′,6′,7′,7a’-tetrahydro-1′H-spiro[indoline-3,5′-pyrrolo[1,2-c][1,3]thiazole]-7′-carbonitrile |
| title_full | 6′-(1,3-Diphenyl-1H-pyrazol-4-yl)-7′-(1H-indol-3-ylcarbonyl)-2-oxo-1-(prop-2-en-1-yl)-5′,6′,7′,7a’-tetrahydro-1′H-spiro[indoline-3,5′-pyrrolo[1,2-c][1,3]thiazole]-7′-carbonitrile |
| title_fullStr | 6′-(1,3-Diphenyl-1H-pyrazol-4-yl)-7′-(1H-indol-3-ylcarbonyl)-2-oxo-1-(prop-2-en-1-yl)-5′,6′,7′,7a’-tetrahydro-1′H-spiro[indoline-3,5′-pyrrolo[1,2-c][1,3]thiazole]-7′-carbonitrile |
| title_full_unstemmed | 6′-(1,3-Diphenyl-1H-pyrazol-4-yl)-7′-(1H-indol-3-ylcarbonyl)-2-oxo-1-(prop-2-en-1-yl)-5′,6′,7′,7a’-tetrahydro-1′H-spiro[indoline-3,5′-pyrrolo[1,2-c][1,3]thiazole]-7′-carbonitrile |
| title_short | 6′-(1,3-Diphenyl-1H-pyrazol-4-yl)-7′-(1H-indol-3-ylcarbonyl)-2-oxo-1-(prop-2-en-1-yl)-5′,6′,7′,7a’-tetrahydro-1′H-spiro[indoline-3,5′-pyrrolo[1,2-c][1,3]thiazole]-7′-carbonitrile |
| title_sort | 6′-(1,3-diphenyl-1h-pyrazol-4-yl)-7′-(1h-indol-3-ylcarbonyl)-2-oxo-1-(prop-2-en-1-yl)-5′,6′,7′,7a’-tetrahydro-1′h-spiro[indoline-3,5′-pyrrolo[1,2-c][1,3]thiazole]-7′-carbonitrile |
| topic | Organic Papers |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684939/ https://www.ncbi.nlm.nih.gov/pubmed/23795041 http://dx.doi.org/10.1107/S1600536813011513 |
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