Rupatadine

In the title compound (systematic name: 8-chloro-11-{1-[(5-methyl­pyridin-3-yl)meth­yl]piperidin-4-yl­idene}-6,11-di­hydro-5H-benzo[5,6]cyclo­hepta­[1,2-b]pyridine), C(26)H(26)ClN(3), the dihedral angle between the mean planes of the chloro­phenyl and cyclo­hepta­[1,2-b]pyridinyl rings fused to the...

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Autores principales: Kaur, Manpreet, Jasinski, Jerry P., Luopa, Zane A., Kumar, Neeraj, Patel, Nilesh G., Gudaparthi, Omprakash, Yathirajan, H. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2013
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685114/
https://www.ncbi.nlm.nih.gov/pubmed/23795133
http://dx.doi.org/10.1107/S1600536813014256
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author Kaur, Manpreet
Jasinski, Jerry P.
Luopa, Zane A.
Kumar, Neeraj
Patel, Nilesh G.
Gudaparthi, Omprakash
Yathirajan, H. S.
author_facet Kaur, Manpreet
Jasinski, Jerry P.
Luopa, Zane A.
Kumar, Neeraj
Patel, Nilesh G.
Gudaparthi, Omprakash
Yathirajan, H. S.
author_sort Kaur, Manpreet
collection PubMed
description In the title compound (systematic name: 8-chloro-11-{1-[(5-methyl­pyridin-3-yl)meth­yl]piperidin-4-yl­idene}-6,11-di­hydro-5H-benzo[5,6]cyclo­hepta­[1,2-b]pyridine), C(26)H(26)ClN(3), the dihedral angle between the mean planes of the chloro­phenyl and cyclo­hepta­[1,2-b]pyridinyl rings fused to the cyclo­heptane ring is 56.6 (1)°. The mean planes of the cyclo­hepta­[1,2-b]pyridinyl and 5-methyl­pyridin-3-yl rings are twisted by 64.9 (4)°. The central piperizene group is in a slightly distorted chair configuration. A weak intra­molecular C—H⋯N inter­action is observed between the cyclo­hepta­[1,2-b]pyridinyl and piperidin-4-yl­idene moieties.
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spelling pubmed-36851142013-06-21 Rupatadine Kaur, Manpreet Jasinski, Jerry P. Luopa, Zane A. Kumar, Neeraj Patel, Nilesh G. Gudaparthi, Omprakash Yathirajan, H. S. Acta Crystallogr Sect E Struct Rep Online Organic Papers In the title compound (systematic name: 8-chloro-11-{1-[(5-methyl­pyridin-3-yl)meth­yl]piperidin-4-yl­idene}-6,11-di­hydro-5H-benzo[5,6]cyclo­hepta­[1,2-b]pyridine), C(26)H(26)ClN(3), the dihedral angle between the mean planes of the chloro­phenyl and cyclo­hepta­[1,2-b]pyridinyl rings fused to the cyclo­heptane ring is 56.6 (1)°. The mean planes of the cyclo­hepta­[1,2-b]pyridinyl and 5-methyl­pyridin-3-yl rings are twisted by 64.9 (4)°. The central piperizene group is in a slightly distorted chair configuration. A weak intra­molecular C—H⋯N inter­action is observed between the cyclo­hepta­[1,2-b]pyridinyl and piperidin-4-yl­idene moieties. International Union of Crystallography 2013-05-31 /pmc/articles/PMC3685114/ /pubmed/23795133 http://dx.doi.org/10.1107/S1600536813014256 Text en © Kaur et al. 2013 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Kaur, Manpreet
Jasinski, Jerry P.
Luopa, Zane A.
Kumar, Neeraj
Patel, Nilesh G.
Gudaparthi, Omprakash
Yathirajan, H. S.
Rupatadine
title Rupatadine
title_full Rupatadine
title_fullStr Rupatadine
title_full_unstemmed Rupatadine
title_short Rupatadine
title_sort rupatadine
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685114/
https://www.ncbi.nlm.nih.gov/pubmed/23795133
http://dx.doi.org/10.1107/S1600536813014256
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