Localized Epigenetic Changes Induced by D(H) Recombination Restricts Recombinase to DJ(H) Junctions

Immunoglobulin heavy chain (Igh) genes are assembled by sequential rearrangements of diversity (D(H)) and variable (V(H)) gene segments. Three critical constraints govern V(H) recombination. These include timing (V(H) recombination follows D(H) recombination), precision (V(H)s recombine only to DJ(H...

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Detalles Bibliográficos
Autores principales: Subrahmanyam, Ramesh, Du, Hansen, Ivanova, Irina, Chakraborty, Tirtha, Ji, Yanhong, Zhang, Yu, Alt, Frederick W., Schatz, David G., Sen, Ranjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685187/
https://www.ncbi.nlm.nih.gov/pubmed/23104096
http://dx.doi.org/10.1038/ni.2447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685187/
https://www.ncbi.nlm.nih.gov/pubmed/23104096
http://dx.doi.org/10.1038/ni.2447

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