Lethal Malaria: Marchiafava and Bignami Were Right

One hundred and twenty years ago, the Italian malariologists Marchiafava and Bignami proposed that the fundamental pathological process underlying lethal falciparum malaria was microvascular obstruction. Since then, several alternative hypotheses have been proposed. These formed the basis for adjunc...

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Detalles Bibliográficos
Autores principales: White, Nicholas J., Turner, Gareth D. H., Day, Nicholas P. J., Dondorp, Arjen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685223/
https://www.ncbi.nlm.nih.gov/pubmed/23585685
http://dx.doi.org/10.1093/infdis/jit116
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author White, Nicholas J.
Turner, Gareth D. H.
Day, Nicholas P. J.
Dondorp, Arjen M.
author_facet White, Nicholas J.
Turner, Gareth D. H.
Day, Nicholas P. J.
Dondorp, Arjen M.
author_sort White, Nicholas J.
collection PubMed
description One hundred and twenty years ago, the Italian malariologists Marchiafava and Bignami proposed that the fundamental pathological process underlying lethal falciparum malaria was microvascular obstruction. Since then, several alternative hypotheses have been proposed. These formed the basis for adjunctive interventions, which have either been ineffective or harmful. Recent evidence strongly suggests that Marchiafava and Bignami were right.
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spelling pubmed-36852232013-06-18 Lethal Malaria: Marchiafava and Bignami Were Right White, Nicholas J. Turner, Gareth D. H. Day, Nicholas P. J. Dondorp, Arjen M. J Infect Dis Review Article One hundred and twenty years ago, the Italian malariologists Marchiafava and Bignami proposed that the fundamental pathological process underlying lethal falciparum malaria was microvascular obstruction. Since then, several alternative hypotheses have been proposed. These formed the basis for adjunctive interventions, which have either been ineffective or harmful. Recent evidence strongly suggests that Marchiafava and Bignami were right. Oxford University Press 2013-07-15 2013-04-12 /pmc/articles/PMC3685223/ /pubmed/23585685 http://dx.doi.org/10.1093/infdis/jit116 Text en © The Author 2013. Published by Oxford University Press on behalf of the Infectious Disease Society of America. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work properly cited. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Review Article
White, Nicholas J.
Turner, Gareth D. H.
Day, Nicholas P. J.
Dondorp, Arjen M.
Lethal Malaria: Marchiafava and Bignami Were Right
title Lethal Malaria: Marchiafava and Bignami Were Right
title_full Lethal Malaria: Marchiafava and Bignami Were Right
title_fullStr Lethal Malaria: Marchiafava and Bignami Were Right
title_full_unstemmed Lethal Malaria: Marchiafava and Bignami Were Right
title_short Lethal Malaria: Marchiafava and Bignami Were Right
title_sort lethal malaria: marchiafava and bignami were right
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685223/
https://www.ncbi.nlm.nih.gov/pubmed/23585685
http://dx.doi.org/10.1093/infdis/jit116
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