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Genetic Evaluation of the Performance of Malaria Parasite Clearance Rate Metrics

Accurate measurement of malaria parasite clearance rates (CRs) following artemisinin (ART) treatment is critical for resistance surveillance and research, and various CR metrics are currently used. We measured 13 CR metrics in 1472 ART-treated hyperparasitemia infections for which 6-hour parasite co...

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Autores principales: Nkhoma, Standwell C., Stepniewska, Kasia, Nair, Shalini, Phyo, Aung Pyae, McGready, Rose, Nosten, François, Anderson, Tim J. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685230/
https://www.ncbi.nlm.nih.gov/pubmed/23592863
http://dx.doi.org/10.1093/infdis/jit165
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author Nkhoma, Standwell C.
Stepniewska, Kasia
Nair, Shalini
Phyo, Aung Pyae
McGready, Rose
Nosten, François
Anderson, Tim J. C.
author_facet Nkhoma, Standwell C.
Stepniewska, Kasia
Nair, Shalini
Phyo, Aung Pyae
McGready, Rose
Nosten, François
Anderson, Tim J. C.
author_sort Nkhoma, Standwell C.
collection PubMed
description Accurate measurement of malaria parasite clearance rates (CRs) following artemisinin (ART) treatment is critical for resistance surveillance and research, and various CR metrics are currently used. We measured 13 CR metrics in 1472 ART-treated hyperparasitemia infections for which 6-hour parasite counts and parasite genotypes (93 single nucleotide polymorphisms [SNPs]) were available. We used heritability to evaluate the performance of each metric. Heritability ranged from 0.06 ± 0.06 (SD) for 50% parasite clearance times to 0.67 ± 0.04 (SD) for clearance half-lives estimated from 6-hour parasite counts. These results identify the measures that should be avoided and show that reliable clearance measures can be obtained with abbreviated monitoring protocols.
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spelling pubmed-36852302013-06-18 Genetic Evaluation of the Performance of Malaria Parasite Clearance Rate Metrics Nkhoma, Standwell C. Stepniewska, Kasia Nair, Shalini Phyo, Aung Pyae McGready, Rose Nosten, François Anderson, Tim J. C. J Infect Dis Major Articles and Brief Reports Accurate measurement of malaria parasite clearance rates (CRs) following artemisinin (ART) treatment is critical for resistance surveillance and research, and various CR metrics are currently used. We measured 13 CR metrics in 1472 ART-treated hyperparasitemia infections for which 6-hour parasite counts and parasite genotypes (93 single nucleotide polymorphisms [SNPs]) were available. We used heritability to evaluate the performance of each metric. Heritability ranged from 0.06 ± 0.06 (SD) for 50% parasite clearance times to 0.67 ± 0.04 (SD) for clearance half-lives estimated from 6-hour parasite counts. These results identify the measures that should be avoided and show that reliable clearance measures can be obtained with abbreviated monitoring protocols. Oxford University Press 2013-07-15 2013-04-16 /pmc/articles/PMC3685230/ /pubmed/23592863 http://dx.doi.org/10.1093/infdis/jit165 Text en © The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work properly cited. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Major Articles and Brief Reports
Nkhoma, Standwell C.
Stepniewska, Kasia
Nair, Shalini
Phyo, Aung Pyae
McGready, Rose
Nosten, François
Anderson, Tim J. C.
Genetic Evaluation of the Performance of Malaria Parasite Clearance Rate Metrics
title Genetic Evaluation of the Performance of Malaria Parasite Clearance Rate Metrics
title_full Genetic Evaluation of the Performance of Malaria Parasite Clearance Rate Metrics
title_fullStr Genetic Evaluation of the Performance of Malaria Parasite Clearance Rate Metrics
title_full_unstemmed Genetic Evaluation of the Performance of Malaria Parasite Clearance Rate Metrics
title_short Genetic Evaluation of the Performance of Malaria Parasite Clearance Rate Metrics
title_sort genetic evaluation of the performance of malaria parasite clearance rate metrics
topic Major Articles and Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685230/
https://www.ncbi.nlm.nih.gov/pubmed/23592863
http://dx.doi.org/10.1093/infdis/jit165
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