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Prognostic value of the Fas/Fas ligand system in breast cancer
Fas and its ligand (FasL) are known to play a crucial role in the genetically controlled mechanism of cell death, and their deregulation in cancer cells is involved in the immune escape of the tumor. The aim of this review is to analyze the current knowledge on the prognostic value of Fas/FasL in br...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685366/ https://www.ncbi.nlm.nih.gov/pubmed/23788976 http://dx.doi.org/10.5114/wo.2013.34612 |
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author | Bębenek, Marek Duś, Danuta Koźlak, Joanna |
author_facet | Bębenek, Marek Duś, Danuta Koźlak, Joanna |
author_sort | Bębenek, Marek |
collection | PubMed |
description | Fas and its ligand (FasL) are known to play a crucial role in the genetically controlled mechanism of cell death, and their deregulation in cancer cells is involved in the immune escape of the tumor. The aim of this review is to analyze the current knowledge on the prognostic value of Fas/FasL in breast cancer patients. Both the results of other authors and our own experiences indicate that the lack of Fas ligand, and particularly Fas, is related to a significantly worse prognosis. It probably results from the resistance of Fas-deficient breast tumors to the mechanisms of apoptosis. On the other hand, some results suggest that the Fas/FasL-dependent mechanisms of tumor spread may be different for various target tissues. The expression of the Fas/Fas-ligand system has potential prognostic application in view of current knowledge, and consequently should be considered as an additional prognostic factor in breast cancer patients. |
format | Online Article Text |
id | pubmed-3685366 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-36853662013-06-20 Prognostic value of the Fas/Fas ligand system in breast cancer Bębenek, Marek Duś, Danuta Koźlak, Joanna Contemp Oncol (Pozn) Review Fas and its ligand (FasL) are known to play a crucial role in the genetically controlled mechanism of cell death, and their deregulation in cancer cells is involved in the immune escape of the tumor. The aim of this review is to analyze the current knowledge on the prognostic value of Fas/FasL in breast cancer patients. Both the results of other authors and our own experiences indicate that the lack of Fas ligand, and particularly Fas, is related to a significantly worse prognosis. It probably results from the resistance of Fas-deficient breast tumors to the mechanisms of apoptosis. On the other hand, some results suggest that the Fas/FasL-dependent mechanisms of tumor spread may be different for various target tissues. The expression of the Fas/Fas-ligand system has potential prognostic application in view of current knowledge, and consequently should be considered as an additional prognostic factor in breast cancer patients. Termedia Publishing House 2013-04-29 2013 /pmc/articles/PMC3685366/ /pubmed/23788976 http://dx.doi.org/10.5114/wo.2013.34612 Text en Copyright © 2013 Termedia http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Bębenek, Marek Duś, Danuta Koźlak, Joanna Prognostic value of the Fas/Fas ligand system in breast cancer |
title | Prognostic value of the Fas/Fas ligand system in breast cancer |
title_full | Prognostic value of the Fas/Fas ligand system in breast cancer |
title_fullStr | Prognostic value of the Fas/Fas ligand system in breast cancer |
title_full_unstemmed | Prognostic value of the Fas/Fas ligand system in breast cancer |
title_short | Prognostic value of the Fas/Fas ligand system in breast cancer |
title_sort | prognostic value of the fas/fas ligand system in breast cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685366/ https://www.ncbi.nlm.nih.gov/pubmed/23788976 http://dx.doi.org/10.5114/wo.2013.34612 |
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