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Exposure to wood smoke increases arterial stiffness and decreases heart rate variability in humans

BACKGROUND: Emissions from biomass combustion are a major source of indoor and outdoor air pollution, and are estimated to cause millions of premature deaths worldwide annually. Whilst adverse respiratory health effects of biomass exposure are well established, less is known about its effects on the...

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Autores principales: Unosson, Jon, Blomberg, Anders, Sandström, Thomas, Muala, Ala, Boman, Christoffer, Nyström, Robin, Westerholm, Roger, Mills, Nicholas L, Newby, David E, Langrish, Jeremy P, Bosson, Jenny A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685524/
https://www.ncbi.nlm.nih.gov/pubmed/23742058
http://dx.doi.org/10.1186/1743-8977-10-20
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author Unosson, Jon
Blomberg, Anders
Sandström, Thomas
Muala, Ala
Boman, Christoffer
Nyström, Robin
Westerholm, Roger
Mills, Nicholas L
Newby, David E
Langrish, Jeremy P
Bosson, Jenny A
author_facet Unosson, Jon
Blomberg, Anders
Sandström, Thomas
Muala, Ala
Boman, Christoffer
Nyström, Robin
Westerholm, Roger
Mills, Nicholas L
Newby, David E
Langrish, Jeremy P
Bosson, Jenny A
author_sort Unosson, Jon
collection PubMed
description BACKGROUND: Emissions from biomass combustion are a major source of indoor and outdoor air pollution, and are estimated to cause millions of premature deaths worldwide annually. Whilst adverse respiratory health effects of biomass exposure are well established, less is known about its effects on the cardiovascular system. In this study we assessed the effect of exposure to wood smoke on heart rate, blood pressure, central arterial stiffness and heart rate variability in otherwise healthy persons. METHODS: Fourteen healthy non-smoking subjects participated in a randomized, double-blind crossover study. Subjects were exposed to dilute wood smoke (mean particle concentration of 314±38 μg/m(3)) or filtered air for three hours during intermittent exercise. Heart rate, blood pressure, central arterial stiffness and heart rate variability were measured at baseline and for one hour post-exposure. RESULTS: Central arterial stiffness, measured as augmentation index, augmentation pressure and pulse wave velocity, was higher after wood smoke exposure as compared to filtered air (p < 0.01 for all), and heart rate was increased (p < 0.01) although there was no effect on blood pressure. Heart rate variability (SDNN, RMSSD and pNN50; p = 0.003, p < 0.001 and p < 0.001 respectively) was decreased one hour following exposure to wood smoke compared to filtered air. CONCLUSIONS: Acute exposure to wood smoke as a model of exposure to biomass combustion is associated with an immediate increase in central arterial stiffness and a simultaneous reduction in heart rate variability. As biomass is used for cooking and heating by a large fraction of the global population and is currently advocated as a sustainable alternative energy source, further studies are required to establish its likely impact on cardiovascular disease. TRIAL REGISTRATION: ClinicalTrials.gov, NCT01488500
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spelling pubmed-36855242013-06-19 Exposure to wood smoke increases arterial stiffness and decreases heart rate variability in humans Unosson, Jon Blomberg, Anders Sandström, Thomas Muala, Ala Boman, Christoffer Nyström, Robin Westerholm, Roger Mills, Nicholas L Newby, David E Langrish, Jeremy P Bosson, Jenny A Part Fibre Toxicol Research BACKGROUND: Emissions from biomass combustion are a major source of indoor and outdoor air pollution, and are estimated to cause millions of premature deaths worldwide annually. Whilst adverse respiratory health effects of biomass exposure are well established, less is known about its effects on the cardiovascular system. In this study we assessed the effect of exposure to wood smoke on heart rate, blood pressure, central arterial stiffness and heart rate variability in otherwise healthy persons. METHODS: Fourteen healthy non-smoking subjects participated in a randomized, double-blind crossover study. Subjects were exposed to dilute wood smoke (mean particle concentration of 314±38 μg/m(3)) or filtered air for three hours during intermittent exercise. Heart rate, blood pressure, central arterial stiffness and heart rate variability were measured at baseline and for one hour post-exposure. RESULTS: Central arterial stiffness, measured as augmentation index, augmentation pressure and pulse wave velocity, was higher after wood smoke exposure as compared to filtered air (p < 0.01 for all), and heart rate was increased (p < 0.01) although there was no effect on blood pressure. Heart rate variability (SDNN, RMSSD and pNN50; p = 0.003, p < 0.001 and p < 0.001 respectively) was decreased one hour following exposure to wood smoke compared to filtered air. CONCLUSIONS: Acute exposure to wood smoke as a model of exposure to biomass combustion is associated with an immediate increase in central arterial stiffness and a simultaneous reduction in heart rate variability. As biomass is used for cooking and heating by a large fraction of the global population and is currently advocated as a sustainable alternative energy source, further studies are required to establish its likely impact on cardiovascular disease. TRIAL REGISTRATION: ClinicalTrials.gov, NCT01488500 BioMed Central 2013-06-06 /pmc/articles/PMC3685524/ /pubmed/23742058 http://dx.doi.org/10.1186/1743-8977-10-20 Text en Copyright © 2013 Unosson et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Unosson, Jon
Blomberg, Anders
Sandström, Thomas
Muala, Ala
Boman, Christoffer
Nyström, Robin
Westerholm, Roger
Mills, Nicholas L
Newby, David E
Langrish, Jeremy P
Bosson, Jenny A
Exposure to wood smoke increases arterial stiffness and decreases heart rate variability in humans
title Exposure to wood smoke increases arterial stiffness and decreases heart rate variability in humans
title_full Exposure to wood smoke increases arterial stiffness and decreases heart rate variability in humans
title_fullStr Exposure to wood smoke increases arterial stiffness and decreases heart rate variability in humans
title_full_unstemmed Exposure to wood smoke increases arterial stiffness and decreases heart rate variability in humans
title_short Exposure to wood smoke increases arterial stiffness and decreases heart rate variability in humans
title_sort exposure to wood smoke increases arterial stiffness and decreases heart rate variability in humans
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685524/
https://www.ncbi.nlm.nih.gov/pubmed/23742058
http://dx.doi.org/10.1186/1743-8977-10-20
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