Septic shock in older people: a prospective cohort study

BACKGROUND: Septic shock is the first cause of death in Intensive Care Units. Despite experimental data showing increased inflammatory response of aged animals following infection, the current accepted hypothesis claims that aged patients are immunocompromised, when compared to young individuals. RE...

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Detalles Bibliográficos
Autores principales: Pinheiro da Silva, Fabiano, Zampieri, Fernando Godinho, Barbeiro, Denise Frediani, Barbeiro, Hermes Vieira, Goulart, Alessandra Carvalho, Torggler Filho, Francisco, Velasco, Irineu Tadeu, da Cruz Neto, Luiz Monteiro, de Souza, Heraldo Possolo, Machado, Marcel Cerqueira César
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685530/
https://www.ncbi.nlm.nih.gov/pubmed/23742671
http://dx.doi.org/10.1186/1742-4933-10-21
Descripción
Sumario:BACKGROUND: Septic shock is the first cause of death in Intensive Care Units. Despite experimental data showing increased inflammatory response of aged animals following infection, the current accepted hypothesis claims that aged patients are immunocompromised, when compared to young individuals. RESULTS: Here, we describe a prospective cohort study designed to analyze the immune profile of this population. CONCLUSION: Older people are as immunocompetent as the young individual, regarding the cytokines, chemokines and growth factors response to devastating infection.

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