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Septic shock in older people: a prospective cohort study
BACKGROUND: Septic shock is the first cause of death in Intensive Care Units. Despite experimental data showing increased inflammatory response of aged animals following infection, the current accepted hypothesis claims that aged patients are immunocompromised, when compared to young individuals. RE...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685530/ https://www.ncbi.nlm.nih.gov/pubmed/23742671 http://dx.doi.org/10.1186/1742-4933-10-21 |
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| author | Pinheiro da Silva, Fabiano Zampieri, Fernando Godinho Barbeiro, Denise Frediani Barbeiro, Hermes Vieira Goulart, Alessandra Carvalho Torggler Filho, Francisco Velasco, Irineu Tadeu da Cruz Neto, Luiz Monteiro de Souza, Heraldo Possolo Machado, Marcel Cerqueira César |
| author_facet | Pinheiro da Silva, Fabiano Zampieri, Fernando Godinho Barbeiro, Denise Frediani Barbeiro, Hermes Vieira Goulart, Alessandra Carvalho Torggler Filho, Francisco Velasco, Irineu Tadeu da Cruz Neto, Luiz Monteiro de Souza, Heraldo Possolo Machado, Marcel Cerqueira César |
| author_sort | Pinheiro da Silva, Fabiano |
| collection | PubMed |
| description | BACKGROUND: Septic shock is the first cause of death in Intensive Care Units. Despite experimental data showing increased inflammatory response of aged animals following infection, the current accepted hypothesis claims that aged patients are immunocompromised, when compared to young individuals. RESULTS: Here, we describe a prospective cohort study designed to analyze the immune profile of this population. CONCLUSION: Older people are as immunocompetent as the young individual, regarding the cytokines, chemokines and growth factors response to devastating infection. |
| format | Online Article Text |
| id | pubmed-3685530 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2013 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-36855302013-06-19 Septic shock in older people: a prospective cohort study Pinheiro da Silva, Fabiano Zampieri, Fernando Godinho Barbeiro, Denise Frediani Barbeiro, Hermes Vieira Goulart, Alessandra Carvalho Torggler Filho, Francisco Velasco, Irineu Tadeu da Cruz Neto, Luiz Monteiro de Souza, Heraldo Possolo Machado, Marcel Cerqueira César Immun Ageing Research BACKGROUND: Septic shock is the first cause of death in Intensive Care Units. Despite experimental data showing increased inflammatory response of aged animals following infection, the current accepted hypothesis claims that aged patients are immunocompromised, when compared to young individuals. RESULTS: Here, we describe a prospective cohort study designed to analyze the immune profile of this population. CONCLUSION: Older people are as immunocompetent as the young individual, regarding the cytokines, chemokines and growth factors response to devastating infection. BioMed Central 2013-06-06 /pmc/articles/PMC3685530/ /pubmed/23742671 http://dx.doi.org/10.1186/1742-4933-10-21 Text en Copyright © 2013 Pinheiro da Silva et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Research Pinheiro da Silva, Fabiano Zampieri, Fernando Godinho Barbeiro, Denise Frediani Barbeiro, Hermes Vieira Goulart, Alessandra Carvalho Torggler Filho, Francisco Velasco, Irineu Tadeu da Cruz Neto, Luiz Monteiro de Souza, Heraldo Possolo Machado, Marcel Cerqueira César Septic shock in older people: a prospective cohort study |
| title | Septic shock in older people: a prospective cohort study |
| title_full | Septic shock in older people: a prospective cohort study |
| title_fullStr | Septic shock in older people: a prospective cohort study |
| title_full_unstemmed | Septic shock in older people: a prospective cohort study |
| title_short | Septic shock in older people: a prospective cohort study |
| title_sort | septic shock in older people: a prospective cohort study |
| topic | Research |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685530/ https://www.ncbi.nlm.nih.gov/pubmed/23742671 http://dx.doi.org/10.1186/1742-4933-10-21 |
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