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New Insights into the Role of the Immune Microenvironment in Breast Carcinoma

Recently, immune edition has been recognized as a new hallmark of cancer. In this respect, some clinical trials in breast cancer have reported imppressive outcomes related to laboratory immune findings, especially in the neoadjuvant and metastatic setting. Infiltration by tumor infiltrating lymphocy...

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Autores principales: de la Cruz-Merino, Luis, Barco-Sánchez, Antonio, Henao Carrasco, Fernando, Nogales Fernández, Esteban, Vallejo Benítez, Ana, Brugal Molina, Javier, Martínez Peinado, Antonio, Grueso López, Ana, Ruiz Borrego, Manuel, Codes Manuel de Villena, Manuel, Sánchez-Margalet, Víctor, Nieto-García, Adoración, Alba Conejo, Emilio, Casares Lagar, Noelia, Ibáñez Martínez, José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686058/
https://www.ncbi.nlm.nih.gov/pubmed/23861693
http://dx.doi.org/10.1155/2013/785317
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author de la Cruz-Merino, Luis
Barco-Sánchez, Antonio
Henao Carrasco, Fernando
Nogales Fernández, Esteban
Vallejo Benítez, Ana
Brugal Molina, Javier
Martínez Peinado, Antonio
Grueso López, Ana
Ruiz Borrego, Manuel
Codes Manuel de Villena, Manuel
Sánchez-Margalet, Víctor
Nieto-García, Adoración
Alba Conejo, Emilio
Casares Lagar, Noelia
Ibáñez Martínez, José
author_facet de la Cruz-Merino, Luis
Barco-Sánchez, Antonio
Henao Carrasco, Fernando
Nogales Fernández, Esteban
Vallejo Benítez, Ana
Brugal Molina, Javier
Martínez Peinado, Antonio
Grueso López, Ana
Ruiz Borrego, Manuel
Codes Manuel de Villena, Manuel
Sánchez-Margalet, Víctor
Nieto-García, Adoración
Alba Conejo, Emilio
Casares Lagar, Noelia
Ibáñez Martínez, José
author_sort de la Cruz-Merino, Luis
collection PubMed
description Recently, immune edition has been recognized as a new hallmark of cancer. In this respect, some clinical trials in breast cancer have reported imppressive outcomes related to laboratory immune findings, especially in the neoadjuvant and metastatic setting. Infiltration by tumor infiltrating lymphocytes (TIL) and their subtypes, tumor-associated macrophages (TAM) and myeloid-derived suppressive cells (MDSC) seem bona fide prognostic and even predictive biomarkers, that will eventually be incorporated into diagnostic and therapeutic algorithms of breast cancer. In addition, the complex interaction of costimulatory and coinhibitory molecules on the immune synapse and the different signals that they may exert represent another exciting field to explore. In this review we try to summarize and elucidate these new concepts and knowledge from a translational perspective focusing on breast cancer, paying special attention to those aspects that might have more significance in clinical practice and could be useful to design successful therapeutic strategies in the future.
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spelling pubmed-36860582013-07-16 New Insights into the Role of the Immune Microenvironment in Breast Carcinoma de la Cruz-Merino, Luis Barco-Sánchez, Antonio Henao Carrasco, Fernando Nogales Fernández, Esteban Vallejo Benítez, Ana Brugal Molina, Javier Martínez Peinado, Antonio Grueso López, Ana Ruiz Borrego, Manuel Codes Manuel de Villena, Manuel Sánchez-Margalet, Víctor Nieto-García, Adoración Alba Conejo, Emilio Casares Lagar, Noelia Ibáñez Martínez, José Clin Dev Immunol Review Article Recently, immune edition has been recognized as a new hallmark of cancer. In this respect, some clinical trials in breast cancer have reported imppressive outcomes related to laboratory immune findings, especially in the neoadjuvant and metastatic setting. Infiltration by tumor infiltrating lymphocytes (TIL) and their subtypes, tumor-associated macrophages (TAM) and myeloid-derived suppressive cells (MDSC) seem bona fide prognostic and even predictive biomarkers, that will eventually be incorporated into diagnostic and therapeutic algorithms of breast cancer. In addition, the complex interaction of costimulatory and coinhibitory molecules on the immune synapse and the different signals that they may exert represent another exciting field to explore. In this review we try to summarize and elucidate these new concepts and knowledge from a translational perspective focusing on breast cancer, paying special attention to those aspects that might have more significance in clinical practice and could be useful to design successful therapeutic strategies in the future. Hindawi Publishing Corporation 2013 2013-06-03 /pmc/articles/PMC3686058/ /pubmed/23861693 http://dx.doi.org/10.1155/2013/785317 Text en Copyright © 2013 Luis de la Cruz-Merino et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
de la Cruz-Merino, Luis
Barco-Sánchez, Antonio
Henao Carrasco, Fernando
Nogales Fernández, Esteban
Vallejo Benítez, Ana
Brugal Molina, Javier
Martínez Peinado, Antonio
Grueso López, Ana
Ruiz Borrego, Manuel
Codes Manuel de Villena, Manuel
Sánchez-Margalet, Víctor
Nieto-García, Adoración
Alba Conejo, Emilio
Casares Lagar, Noelia
Ibáñez Martínez, José
New Insights into the Role of the Immune Microenvironment in Breast Carcinoma
title New Insights into the Role of the Immune Microenvironment in Breast Carcinoma
title_full New Insights into the Role of the Immune Microenvironment in Breast Carcinoma
title_fullStr New Insights into the Role of the Immune Microenvironment in Breast Carcinoma
title_full_unstemmed New Insights into the Role of the Immune Microenvironment in Breast Carcinoma
title_short New Insights into the Role of the Immune Microenvironment in Breast Carcinoma
title_sort new insights into the role of the immune microenvironment in breast carcinoma
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686058/
https://www.ncbi.nlm.nih.gov/pubmed/23861693
http://dx.doi.org/10.1155/2013/785317
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