Cargando…

Polycyclic aromatic hydrocarbons: determinants of urinary 1-hydroxypyrene glucuronide concentration and risk of colorectal cancer in the Shanghai Women’s Health Study

BACKGROUND: Associations between polycyclic aromatic hydrocarbons (PAHs) and colorectal cancer have been reported previously but few studies have characterized PAH exposure using biological measurements. We evaluated colorectal cancer risk in relation to urinary concentration of 1-hydroxypyrene gluc...

Descripción completa

Detalles Bibliográficos
Autores principales: Hofmann, Jonathan N, Liao, Linda M, Strickland, Paul T, Shu, Xiao-Ou, Yang, Gong, Ji, Bu-Tian, Li, Hong-Lan, Rothman, Nathaniel, Kamangar, Farin, Gao, Yu-Tang, Zheng, Wei, Chow, Wong-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686696/
https://www.ncbi.nlm.nih.gov/pubmed/23758680
http://dx.doi.org/10.1186/1471-2407-13-282
_version_ 1782273817702301696
author Hofmann, Jonathan N
Liao, Linda M
Strickland, Paul T
Shu, Xiao-Ou
Yang, Gong
Ji, Bu-Tian
Li, Hong-Lan
Rothman, Nathaniel
Kamangar, Farin
Gao, Yu-Tang
Zheng, Wei
Chow, Wong-Ho
author_facet Hofmann, Jonathan N
Liao, Linda M
Strickland, Paul T
Shu, Xiao-Ou
Yang, Gong
Ji, Bu-Tian
Li, Hong-Lan
Rothman, Nathaniel
Kamangar, Farin
Gao, Yu-Tang
Zheng, Wei
Chow, Wong-Ho
author_sort Hofmann, Jonathan N
collection PubMed
description BACKGROUND: Associations between polycyclic aromatic hydrocarbons (PAHs) and colorectal cancer have been reported previously but few studies have characterized PAH exposure using biological measurements. We evaluated colorectal cancer risk in relation to urinary concentration of 1-hydroxypyrene glucuronide (1-OHPG), a polycyclic aromatic hydrocarbon (PAH) metabolite, and assessed determinants of PAH exposure among controls in the Shanghai Women’s Health Study (SWHS). METHODS: Concentrations of 1-OHPG were measured in spot urine samples collected from 343 colorectal cancer cases and 343 individually matched controls. Questionnaires were administered to collect information on demographic characteristics and reported exposures. Odds ratios were calculated for risk of colorectal cancer in relation to quartiles of urinary 1-OHPG concentration. Potential determinants of natural log-transformed urinary 1-OHPG concentration were evaluated among a combined sample of controls from this study and another nested case–control study in the SWHS (N(total)=652). RESULTS: No statistically significant differences in risk of colorectal cancer by urinary 1-OHPG levels were observed. Among controls, the median (interquartile range) urinary 1-OHPG concentration was 2.01 pmol/mL (0.95-4.09). Active and passive smoking, using coal as a cooking fuel, eating foods that were cooked well done, and recent consumption of fried dough (e.g., yóutiáo) were associated with elevated levels of 1-OHPG, though only active smoking and fried dough consumption achieved statistical significance in multivariate analyses. CONCLUSIONS: This study does not provide evidence of an association between urinary levels of 1-OHPG and risk of colorectal cancer among women. Several environmental and dietary sources of PAH exposure were identified. Overall, the levels of 1-OHPG in this population of predominantly non-smoking women were considerably higher than levels typically observed among non-smokers in Europe, North America, and other developed regions.
format Online
Article
Text
id pubmed-3686696
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-36866962013-06-20 Polycyclic aromatic hydrocarbons: determinants of urinary 1-hydroxypyrene glucuronide concentration and risk of colorectal cancer in the Shanghai Women’s Health Study Hofmann, Jonathan N Liao, Linda M Strickland, Paul T Shu, Xiao-Ou Yang, Gong Ji, Bu-Tian Li, Hong-Lan Rothman, Nathaniel Kamangar, Farin Gao, Yu-Tang Zheng, Wei Chow, Wong-Ho BMC Cancer Research Article BACKGROUND: Associations between polycyclic aromatic hydrocarbons (PAHs) and colorectal cancer have been reported previously but few studies have characterized PAH exposure using biological measurements. We evaluated colorectal cancer risk in relation to urinary concentration of 1-hydroxypyrene glucuronide (1-OHPG), a polycyclic aromatic hydrocarbon (PAH) metabolite, and assessed determinants of PAH exposure among controls in the Shanghai Women’s Health Study (SWHS). METHODS: Concentrations of 1-OHPG were measured in spot urine samples collected from 343 colorectal cancer cases and 343 individually matched controls. Questionnaires were administered to collect information on demographic characteristics and reported exposures. Odds ratios were calculated for risk of colorectal cancer in relation to quartiles of urinary 1-OHPG concentration. Potential determinants of natural log-transformed urinary 1-OHPG concentration were evaluated among a combined sample of controls from this study and another nested case–control study in the SWHS (N(total)=652). RESULTS: No statistically significant differences in risk of colorectal cancer by urinary 1-OHPG levels were observed. Among controls, the median (interquartile range) urinary 1-OHPG concentration was 2.01 pmol/mL (0.95-4.09). Active and passive smoking, using coal as a cooking fuel, eating foods that were cooked well done, and recent consumption of fried dough (e.g., yóutiáo) were associated with elevated levels of 1-OHPG, though only active smoking and fried dough consumption achieved statistical significance in multivariate analyses. CONCLUSIONS: This study does not provide evidence of an association between urinary levels of 1-OHPG and risk of colorectal cancer among women. Several environmental and dietary sources of PAH exposure were identified. Overall, the levels of 1-OHPG in this population of predominantly non-smoking women were considerably higher than levels typically observed among non-smokers in Europe, North America, and other developed regions. BioMed Central 2013-06-11 /pmc/articles/PMC3686696/ /pubmed/23758680 http://dx.doi.org/10.1186/1471-2407-13-282 Text en Copyright © 2013 Hofmann et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Hofmann, Jonathan N
Liao, Linda M
Strickland, Paul T
Shu, Xiao-Ou
Yang, Gong
Ji, Bu-Tian
Li, Hong-Lan
Rothman, Nathaniel
Kamangar, Farin
Gao, Yu-Tang
Zheng, Wei
Chow, Wong-Ho
Polycyclic aromatic hydrocarbons: determinants of urinary 1-hydroxypyrene glucuronide concentration and risk of colorectal cancer in the Shanghai Women’s Health Study
title Polycyclic aromatic hydrocarbons: determinants of urinary 1-hydroxypyrene glucuronide concentration and risk of colorectal cancer in the Shanghai Women’s Health Study
title_full Polycyclic aromatic hydrocarbons: determinants of urinary 1-hydroxypyrene glucuronide concentration and risk of colorectal cancer in the Shanghai Women’s Health Study
title_fullStr Polycyclic aromatic hydrocarbons: determinants of urinary 1-hydroxypyrene glucuronide concentration and risk of colorectal cancer in the Shanghai Women’s Health Study
title_full_unstemmed Polycyclic aromatic hydrocarbons: determinants of urinary 1-hydroxypyrene glucuronide concentration and risk of colorectal cancer in the Shanghai Women’s Health Study
title_short Polycyclic aromatic hydrocarbons: determinants of urinary 1-hydroxypyrene glucuronide concentration and risk of colorectal cancer in the Shanghai Women’s Health Study
title_sort polycyclic aromatic hydrocarbons: determinants of urinary 1-hydroxypyrene glucuronide concentration and risk of colorectal cancer in the shanghai women’s health study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686696/
https://www.ncbi.nlm.nih.gov/pubmed/23758680
http://dx.doi.org/10.1186/1471-2407-13-282
work_keys_str_mv AT hofmannjonathann polycyclicaromatichydrocarbonsdeterminantsofurinary1hydroxypyreneglucuronideconcentrationandriskofcolorectalcancerintheshanghaiwomenshealthstudy
AT liaolindam polycyclicaromatichydrocarbonsdeterminantsofurinary1hydroxypyreneglucuronideconcentrationandriskofcolorectalcancerintheshanghaiwomenshealthstudy
AT stricklandpault polycyclicaromatichydrocarbonsdeterminantsofurinary1hydroxypyreneglucuronideconcentrationandriskofcolorectalcancerintheshanghaiwomenshealthstudy
AT shuxiaoou polycyclicaromatichydrocarbonsdeterminantsofurinary1hydroxypyreneglucuronideconcentrationandriskofcolorectalcancerintheshanghaiwomenshealthstudy
AT yanggong polycyclicaromatichydrocarbonsdeterminantsofurinary1hydroxypyreneglucuronideconcentrationandriskofcolorectalcancerintheshanghaiwomenshealthstudy
AT jibutian polycyclicaromatichydrocarbonsdeterminantsofurinary1hydroxypyreneglucuronideconcentrationandriskofcolorectalcancerintheshanghaiwomenshealthstudy
AT lihonglan polycyclicaromatichydrocarbonsdeterminantsofurinary1hydroxypyreneglucuronideconcentrationandriskofcolorectalcancerintheshanghaiwomenshealthstudy
AT rothmannathaniel polycyclicaromatichydrocarbonsdeterminantsofurinary1hydroxypyreneglucuronideconcentrationandriskofcolorectalcancerintheshanghaiwomenshealthstudy
AT kamangarfarin polycyclicaromatichydrocarbonsdeterminantsofurinary1hydroxypyreneglucuronideconcentrationandriskofcolorectalcancerintheshanghaiwomenshealthstudy
AT gaoyutang polycyclicaromatichydrocarbonsdeterminantsofurinary1hydroxypyreneglucuronideconcentrationandriskofcolorectalcancerintheshanghaiwomenshealthstudy
AT zhengwei polycyclicaromatichydrocarbonsdeterminantsofurinary1hydroxypyreneglucuronideconcentrationandriskofcolorectalcancerintheshanghaiwomenshealthstudy
AT chowwongho polycyclicaromatichydrocarbonsdeterminantsofurinary1hydroxypyreneglucuronideconcentrationandriskofcolorectalcancerintheshanghaiwomenshealthstudy