Overexpression of MTA3 Correlates with Tumor Progression in Non-Small Cell Lung Cancer

The objective of the current study was to investigate the expression pattern and clinicopathological significance of MTA3 in patients with non-small cell lung cancer (NSCLC). The expression profile of MTA3 in NSCLC tissues and adjacent noncancerous lung tissues was detected by immunohistochemistry....

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Autores principales: Li, Haiying, Sun, Liangliang, Xu, Ying, Li, Zixuan, Luo, Wenting, Tang, Zhongping, Qiu, Xueshan, Wang, Enhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686714/
https://www.ncbi.nlm.nih.gov/pubmed/23840517
http://dx.doi.org/10.1371/journal.pone.0066679
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author Li, Haiying
Sun, Liangliang
Xu, Ying
Li, Zixuan
Luo, Wenting
Tang, Zhongping
Qiu, Xueshan
Wang, Enhua
author_facet Li, Haiying
Sun, Liangliang
Xu, Ying
Li, Zixuan
Luo, Wenting
Tang, Zhongping
Qiu, Xueshan
Wang, Enhua
author_sort Li, Haiying
collection PubMed
description The objective of the current study was to investigate the expression pattern and clinicopathological significance of MTA3 in patients with non-small cell lung cancer (NSCLC). The expression profile of MTA3 in NSCLC tissues and adjacent noncancerous lung tissues was detected by immunohistochemistry. MTA3 was overexpressed in 62 of 108 (57.4%) human lung cancer samples and correlated with p-TNM stage (p<0.0001), nodal metastasis (p = 0.0009) and poor prognosis (p<0.05). In addition, the depletion of MTA3 expression with small interfering RNAs inhibited cell growth and colony formation in the A549 and H157 lung cancer cell lines. Moreover, MTA3 depletion induced cell cycle arrest at the G1/S boundary. Western blotting analysis revealed that the knockdown of MTA3 decreased the protein levels of cyclin A, cyclin D1 and p-Rb. These results indicate that MTA3 plays an important role in NSCLC progression.
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spelling pubmed-36867142013-07-09 Overexpression of MTA3 Correlates with Tumor Progression in Non-Small Cell Lung Cancer Li, Haiying Sun, Liangliang Xu, Ying Li, Zixuan Luo, Wenting Tang, Zhongping Qiu, Xueshan Wang, Enhua PLoS One Research Article The objective of the current study was to investigate the expression pattern and clinicopathological significance of MTA3 in patients with non-small cell lung cancer (NSCLC). The expression profile of MTA3 in NSCLC tissues and adjacent noncancerous lung tissues was detected by immunohistochemistry. MTA3 was overexpressed in 62 of 108 (57.4%) human lung cancer samples and correlated with p-TNM stage (p<0.0001), nodal metastasis (p = 0.0009) and poor prognosis (p<0.05). In addition, the depletion of MTA3 expression with small interfering RNAs inhibited cell growth and colony formation in the A549 and H157 lung cancer cell lines. Moreover, MTA3 depletion induced cell cycle arrest at the G1/S boundary. Western blotting analysis revealed that the knockdown of MTA3 decreased the protein levels of cyclin A, cyclin D1 and p-Rb. These results indicate that MTA3 plays an important role in NSCLC progression. Public Library of Science 2013-06-19 /pmc/articles/PMC3686714/ /pubmed/23840517 http://dx.doi.org/10.1371/journal.pone.0066679 Text en © 2013 Li et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Li, Haiying
Sun, Liangliang
Xu, Ying
Li, Zixuan
Luo, Wenting
Tang, Zhongping
Qiu, Xueshan
Wang, Enhua
Overexpression of MTA3 Correlates with Tumor Progression in Non-Small Cell Lung Cancer
title Overexpression of MTA3 Correlates with Tumor Progression in Non-Small Cell Lung Cancer
title_full Overexpression of MTA3 Correlates with Tumor Progression in Non-Small Cell Lung Cancer
title_fullStr Overexpression of MTA3 Correlates with Tumor Progression in Non-Small Cell Lung Cancer
title_full_unstemmed Overexpression of MTA3 Correlates with Tumor Progression in Non-Small Cell Lung Cancer
title_short Overexpression of MTA3 Correlates with Tumor Progression in Non-Small Cell Lung Cancer
title_sort overexpression of mta3 correlates with tumor progression in non-small cell lung cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686714/
https://www.ncbi.nlm.nih.gov/pubmed/23840517
http://dx.doi.org/10.1371/journal.pone.0066679
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