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CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5′-Diphosphate Ribose Template

Few inhibitors exist for CD38, a multifunctional enzyme catalyzing the formation and metabolism of the Ca(2+)-mobilizing second messenger cyclic adenosine 5′-diphosphoribose (cADPR). Synthetic, non-hydrolyzable ligands can facilitate structure-based inhibitor design. Molecular docking was used to re...

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Detalles Bibliográficos
Autores principales:	Moreau, Christelle, Liu, Qun, Graeff, Richard, Wagner, Gerd K., Thomas, Mark P., Swarbrick, Joanna M., Shuto, Satoshi, Lee, Hon Cheung, Hao, Quan, Potter, Barry V. L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686795/ https://www.ncbi.nlm.nih.gov/pubmed/23840430 http://dx.doi.org/10.1371/journal.pone.0066247

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