A New Transgenic Mouse Model for Studying the Neurotoxicity of Spermine Oxidase Dosage in the Response to Excitotoxic Injury

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Spermine oxidase is a FAD-containing enzyme involved in polyamines catabolism, selectively oxidizing spermine to produce H(2)O(2), spermidine, and 3-aminopropanal. Spermine oxidase is highly expressed in the mouse brain and plays a key role in regulating the levels of spermine, which is involved in...

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Detalles Bibliográficos
Autores principales: Cervelli, Manuela, Bellavia, Gabriella, D'Amelio, Marcello, Cavallucci, Virve, Moreno, Sandra, Berger, Joachim, Nardacci, Roberta, Marcoli, Manuela, Maura, Guido, Piacentini, Mauro, Amendola, Roberto, Cecconi, Francesco, Mariottini, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686797/
https://www.ncbi.nlm.nih.gov/pubmed/23840306
http://dx.doi.org/10.1371/journal.pone.0064810
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