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Influenza Illness and Hospitalizations Averted by Influenza Vaccination in the United States, 2005–2011

CONTEXT: The goal of influenza vaccination programs is to reduce influenza-associated disease outcomes. Therefore, estimating the reduced burden of influenza as a result of vaccination over time and by age group would allow for a clear understanding of the value of influenza vaccines in the US, and...

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Autores principales: Kostova, Deliana, Reed, Carrie, Finelli, Lyn, Cheng, Po-Yung, Gargiullo, Paul M., Shay, David K., Singleton, James A., Meltzer, Martin I., Lu, Peng-jun, Bresee, Joseph S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686813/
https://www.ncbi.nlm.nih.gov/pubmed/23840439
http://dx.doi.org/10.1371/journal.pone.0066312
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author Kostova, Deliana
Reed, Carrie
Finelli, Lyn
Cheng, Po-Yung
Gargiullo, Paul M.
Shay, David K.
Singleton, James A.
Meltzer, Martin I.
Lu, Peng-jun
Bresee, Joseph S.
author_facet Kostova, Deliana
Reed, Carrie
Finelli, Lyn
Cheng, Po-Yung
Gargiullo, Paul M.
Shay, David K.
Singleton, James A.
Meltzer, Martin I.
Lu, Peng-jun
Bresee, Joseph S.
author_sort Kostova, Deliana
collection PubMed
description CONTEXT: The goal of influenza vaccination programs is to reduce influenza-associated disease outcomes. Therefore, estimating the reduced burden of influenza as a result of vaccination over time and by age group would allow for a clear understanding of the value of influenza vaccines in the US, and of areas where improvements could lead to greatest benefits. OBJECTIVE: To estimate the direct effect of influenza vaccination in the US in terms of averted number of cases, medically-attended cases, and hospitalizations over six recent influenza seasons. DESIGN: Using existing surveillance data, we present a method for assessing the impact of influenza vaccination where impact is defined as either the number of averted outcomes or as the prevented disease fraction (the number of cases estimated to have been averted relative to the number of cases that would have occurred in the absence of vaccination). RESULTS: We estimated that during our 6-year study period, the number of influenza illnesses averted by vaccination ranged from a low of approximately 1.1 million (95% confidence interval (CI) 0.6–1.7 million) during the 2006–2007 season to a high of 5 million (CI 2.9–8.6 million) during the 2010–2011 season while the number of averted hospitalizations ranged from a low of 7,700 (CI 3,700–14,100) in 2009–2010 to a high of 40,400 (CI 20,800–73,000) in 2010–2011. Prevented fractions varied across age groups and over time. The highest prevented fraction in the study period was observed in 2010–2011, reflecting the post-pandemic expansion of vaccination coverage. CONCLUSIONS: Influenza vaccination programs in the US produce a substantial health benefit in terms of averted cases, clinic visits and hospitalizations. Our results underscore the potential for additional disease prevention through increased vaccination coverage, particularly among nonelderly adults, and increased vaccine effectiveness, particularly among the elderly.
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spelling pubmed-36868132013-07-09 Influenza Illness and Hospitalizations Averted by Influenza Vaccination in the United States, 2005–2011 Kostova, Deliana Reed, Carrie Finelli, Lyn Cheng, Po-Yung Gargiullo, Paul M. Shay, David K. Singleton, James A. Meltzer, Martin I. Lu, Peng-jun Bresee, Joseph S. PLoS One Research Article CONTEXT: The goal of influenza vaccination programs is to reduce influenza-associated disease outcomes. Therefore, estimating the reduced burden of influenza as a result of vaccination over time and by age group would allow for a clear understanding of the value of influenza vaccines in the US, and of areas where improvements could lead to greatest benefits. OBJECTIVE: To estimate the direct effect of influenza vaccination in the US in terms of averted number of cases, medically-attended cases, and hospitalizations over six recent influenza seasons. DESIGN: Using existing surveillance data, we present a method for assessing the impact of influenza vaccination where impact is defined as either the number of averted outcomes or as the prevented disease fraction (the number of cases estimated to have been averted relative to the number of cases that would have occurred in the absence of vaccination). RESULTS: We estimated that during our 6-year study period, the number of influenza illnesses averted by vaccination ranged from a low of approximately 1.1 million (95% confidence interval (CI) 0.6–1.7 million) during the 2006–2007 season to a high of 5 million (CI 2.9–8.6 million) during the 2010–2011 season while the number of averted hospitalizations ranged from a low of 7,700 (CI 3,700–14,100) in 2009–2010 to a high of 40,400 (CI 20,800–73,000) in 2010–2011. Prevented fractions varied across age groups and over time. The highest prevented fraction in the study period was observed in 2010–2011, reflecting the post-pandemic expansion of vaccination coverage. CONCLUSIONS: Influenza vaccination programs in the US produce a substantial health benefit in terms of averted cases, clinic visits and hospitalizations. Our results underscore the potential for additional disease prevention through increased vaccination coverage, particularly among nonelderly adults, and increased vaccine effectiveness, particularly among the elderly. Public Library of Science 2013-06-19 /pmc/articles/PMC3686813/ /pubmed/23840439 http://dx.doi.org/10.1371/journal.pone.0066312 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
spellingShingle Research Article
Kostova, Deliana
Reed, Carrie
Finelli, Lyn
Cheng, Po-Yung
Gargiullo, Paul M.
Shay, David K.
Singleton, James A.
Meltzer, Martin I.
Lu, Peng-jun
Bresee, Joseph S.
Influenza Illness and Hospitalizations Averted by Influenza Vaccination in the United States, 2005–2011
title Influenza Illness and Hospitalizations Averted by Influenza Vaccination in the United States, 2005–2011
title_full Influenza Illness and Hospitalizations Averted by Influenza Vaccination in the United States, 2005–2011
title_fullStr Influenza Illness and Hospitalizations Averted by Influenza Vaccination in the United States, 2005–2011
title_full_unstemmed Influenza Illness and Hospitalizations Averted by Influenza Vaccination in the United States, 2005–2011
title_short Influenza Illness and Hospitalizations Averted by Influenza Vaccination in the United States, 2005–2011
title_sort influenza illness and hospitalizations averted by influenza vaccination in the united states, 2005–2011
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686813/
https://www.ncbi.nlm.nih.gov/pubmed/23840439
http://dx.doi.org/10.1371/journal.pone.0066312
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