Cargando…

c-Myc oncogene expression in selected odontogenic cysts and tumors: An immunohistochemical study

AIM: To investigate the role of c-Myc oncogene in selected odontogenic cysts and tumors. MATERIALS AND METHODS: Ten cases each of ameloblastoma, adenomatoid odontogenic tumor (AOT), odontogenic keratocyst (OKC), dentigerous cyst, and radicular cyst were selected and primary monoclonal mouse anti-hum...

Descripción completa

Detalles Bibliográficos
Autores principales: Moosvi, Zama, Rekha, K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687189/
https://www.ncbi.nlm.nih.gov/pubmed/23798830
http://dx.doi.org/10.4103/0973-029X.110725
_version_ 1782273877639954432
author Moosvi, Zama
Rekha, K
author_facet Moosvi, Zama
Rekha, K
author_sort Moosvi, Zama
collection PubMed
description AIM: To investigate the role of c-Myc oncogene in selected odontogenic cysts and tumors. MATERIALS AND METHODS: Ten cases each of ameloblastoma, adenomatoid odontogenic tumor (AOT), odontogenic keratocyst (OKC), dentigerous cyst, and radicular cyst were selected and primary monoclonal mouse anti-human c-Myc antibody was used in a dilution of 1: 50. Statistical Analysis was performed using Mann Whitney U test. RESULTS: 80% positivity was observed in ameloblastoma, AOT and OKC; 50% positivity in radicular cyst and 20% positivity in dentigerous cyst. Comparison of c-Myc expression between ameloblastoma and AOT did not reveal significant results. Similarly, no statistical significance was observed when results of OKC were compared with ameloblastoma and AOT. In contrast, significant differences were seen on comparison of dentigerous cyst with ameloblastoma and AOT and radicular cyst with AOT. CONCLUSION: From the above data we conclude that (1) Ameloblastoma and AOT have similar proliferative potential and their biologic behavior cannot possibly be attributed to it. (2) OKC has an intrinsic growth potential which is absent in other cysts and reinforces its classification as keratocystic odontogenic tumor.
format Online
Article
Text
id pubmed-3687189
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-36871892013-06-24 c-Myc oncogene expression in selected odontogenic cysts and tumors: An immunohistochemical study Moosvi, Zama Rekha, K J Oral Maxillofac Pathol Original Article AIM: To investigate the role of c-Myc oncogene in selected odontogenic cysts and tumors. MATERIALS AND METHODS: Ten cases each of ameloblastoma, adenomatoid odontogenic tumor (AOT), odontogenic keratocyst (OKC), dentigerous cyst, and radicular cyst were selected and primary monoclonal mouse anti-human c-Myc antibody was used in a dilution of 1: 50. Statistical Analysis was performed using Mann Whitney U test. RESULTS: 80% positivity was observed in ameloblastoma, AOT and OKC; 50% positivity in radicular cyst and 20% positivity in dentigerous cyst. Comparison of c-Myc expression between ameloblastoma and AOT did not reveal significant results. Similarly, no statistical significance was observed when results of OKC were compared with ameloblastoma and AOT. In contrast, significant differences were seen on comparison of dentigerous cyst with ameloblastoma and AOT and radicular cyst with AOT. CONCLUSION: From the above data we conclude that (1) Ameloblastoma and AOT have similar proliferative potential and their biologic behavior cannot possibly be attributed to it. (2) OKC has an intrinsic growth potential which is absent in other cysts and reinforces its classification as keratocystic odontogenic tumor. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3687189/ /pubmed/23798830 http://dx.doi.org/10.4103/0973-029X.110725 Text en Copyright: © Journal of Oral and Maxillofacial Pathology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Moosvi, Zama
Rekha, K
c-Myc oncogene expression in selected odontogenic cysts and tumors: An immunohistochemical study
title c-Myc oncogene expression in selected odontogenic cysts and tumors: An immunohistochemical study
title_full c-Myc oncogene expression in selected odontogenic cysts and tumors: An immunohistochemical study
title_fullStr c-Myc oncogene expression in selected odontogenic cysts and tumors: An immunohistochemical study
title_full_unstemmed c-Myc oncogene expression in selected odontogenic cysts and tumors: An immunohistochemical study
title_short c-Myc oncogene expression in selected odontogenic cysts and tumors: An immunohistochemical study
title_sort c-myc oncogene expression in selected odontogenic cysts and tumors: an immunohistochemical study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687189/
https://www.ncbi.nlm.nih.gov/pubmed/23798830
http://dx.doi.org/10.4103/0973-029X.110725
work_keys_str_mv AT moosvizama cmyconcogeneexpressioninselectedodontogeniccystsandtumorsanimmunohistochemicalstudy
AT rekhak cmyconcogeneexpressioninselectedodontogeniccystsandtumorsanimmunohistochemicalstudy