Intrinsic Disorder in PTEN and its Interactome Confers Structural Plasticity and Functional Versatility

IDPs, while structurally poor, are functionally rich by virtue of their flexibility and modularity. However, how mutations in IDPs elicit diseases, remain elusive. Herein, we have identified tumor suppressor PTEN as an intrinsically disordered protein (IDP) and elucidated the molecular principles by...

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Detalles Bibliográficos
Autores principales: Malaney, Prerna, Pathak, Ravi Ramesh, Xue, Bin, Uversky, Vladimir N., Davé, Vrushank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687229/
https://www.ncbi.nlm.nih.gov/pubmed/23783762
http://dx.doi.org/10.1038/srep02035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687229/
https://www.ncbi.nlm.nih.gov/pubmed/23783762
http://dx.doi.org/10.1038/srep02035

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