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Expression of c-kit protein in cancer vs. normal breast tissue
AIM OF THE STUDY: There are at least four main signal transduction pathways within human cells which are activated by interaction of an extracellular ligand with its corresponding receptors. One of them is activation of protein kinase. Actually, any of these proteins at any level of the signaling ca...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687431/ https://www.ncbi.nlm.nih.gov/pubmed/23788899 http://dx.doi.org/10.5114/wo.2012.30058 |
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author | Talaiezadeh, Abdolhassan Jazayeri, Seyed Nematollah Nateghi, Jamal |
author_facet | Talaiezadeh, Abdolhassan Jazayeri, Seyed Nematollah Nateghi, Jamal |
author_sort | Talaiezadeh, Abdolhassan |
collection | PubMed |
description | AIM OF THE STUDY: There are at least four main signal transduction pathways within human cells which are activated by interaction of an extracellular ligand with its corresponding receptors. One of them is activation of protein kinase. Actually, any of these proteins at any level of the signaling cascade in a human cell can undergo mutation and cause irregular cellular proliferation and finally result in cancer. C-kit is alternatively called stem cell factor receptor (SCFR) or CD117. It appears that lack of c-kit expression accompanies progression of some tumors, e.g. lung, breast, GIST. The aim of this study was to evaluate C-kit protein expression level within cancer cases. MATERIAL AND METHODS: Sixty specimens of breast cancer and 60 non-cancerous breast tissue specimens were evaluated by IHC for C-kit presentation. We used positive GIST slides as controls. Epi-info ver 6.04 (CDC, WHO) was used for analysis. RESULTS: C-kit was negative in all breast cancer specimens. C-kit was negative in 47 (78%) of 60 non-cancerous breast tissue specimens, but was positive in 13 (22%) of them (p < 0.0001). CONCLUSIONS: There is a reduction in C-kit expression with malignant transformation of breast epithelium. C-kit is believed to play a role in breast carcinogenesis. However, we should follow patients with normal or benign breast tissue to indicate any correlation between C-kit presentation and breast cancer development. |
format | Online Article Text |
id | pubmed-3687431 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-36874312013-06-20 Expression of c-kit protein in cancer vs. normal breast tissue Talaiezadeh, Abdolhassan Jazayeri, Seyed Nematollah Nateghi, Jamal Contemp Oncol (Pozn) Original Paper AIM OF THE STUDY: There are at least four main signal transduction pathways within human cells which are activated by interaction of an extracellular ligand with its corresponding receptors. One of them is activation of protein kinase. Actually, any of these proteins at any level of the signaling cascade in a human cell can undergo mutation and cause irregular cellular proliferation and finally result in cancer. C-kit is alternatively called stem cell factor receptor (SCFR) or CD117. It appears that lack of c-kit expression accompanies progression of some tumors, e.g. lung, breast, GIST. The aim of this study was to evaluate C-kit protein expression level within cancer cases. MATERIAL AND METHODS: Sixty specimens of breast cancer and 60 non-cancerous breast tissue specimens were evaluated by IHC for C-kit presentation. We used positive GIST slides as controls. Epi-info ver 6.04 (CDC, WHO) was used for analysis. RESULTS: C-kit was negative in all breast cancer specimens. C-kit was negative in 47 (78%) of 60 non-cancerous breast tissue specimens, but was positive in 13 (22%) of them (p < 0.0001). CONCLUSIONS: There is a reduction in C-kit expression with malignant transformation of breast epithelium. C-kit is believed to play a role in breast carcinogenesis. However, we should follow patients with normal or benign breast tissue to indicate any correlation between C-kit presentation and breast cancer development. Termedia Publishing House 2012-09-29 2012 /pmc/articles/PMC3687431/ /pubmed/23788899 http://dx.doi.org/10.5114/wo.2012.30058 Text en Copyright © 2012 Termedia http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Paper Talaiezadeh, Abdolhassan Jazayeri, Seyed Nematollah Nateghi, Jamal Expression of c-kit protein in cancer vs. normal breast tissue |
title | Expression of c-kit protein in cancer vs. normal breast tissue |
title_full | Expression of c-kit protein in cancer vs. normal breast tissue |
title_fullStr | Expression of c-kit protein in cancer vs. normal breast tissue |
title_full_unstemmed | Expression of c-kit protein in cancer vs. normal breast tissue |
title_short | Expression of c-kit protein in cancer vs. normal breast tissue |
title_sort | expression of c-kit protein in cancer vs. normal breast tissue |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687431/ https://www.ncbi.nlm.nih.gov/pubmed/23788899 http://dx.doi.org/10.5114/wo.2012.30058 |
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