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Mechanisms of resistance to reversible inhibitors of EGFR tyrosine kinase in non-small cell lung cancer

Abnormalities of epidermal growth factor receptor (EGFR) in non-small-cell lung cancer (NSCLC) patients consist of EGFR overexpression and EGFR (HER1) gene mutations. Structural dysfunction of the tyrosine kinase domain of EGFR is associated with the clinical response to tyrosine kinase inhibitors (...

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Detalles Bibliográficos
Autores principales:	Krawczyk, Paweł, Mlak, Radosław, Powrózek, Tomasz, Nicoś, Marcin, Kowalski, Dariusz M., Wojas-Krawczyk, Kamila, Milanowski, Janusz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Termedia Publishing House 2012
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687444/ https://www.ncbi.nlm.nih.gov/pubmed/23788917 http://dx.doi.org/10.5114/wo.2012.31768

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