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Contemporary methods of therapy and follow-up of neuroendocrine tumours of the gastrointestinal tract and the pancreas
The growing interest in neuroendocrine tumours is due to the dynamic growth of detection of this type of cancer. Neuroendocrine tumours (neuroendocrine neoplasms – NENs / neuroendocrine tumours – NETs) derive from glands, groups of endocrine cells and diffuse neuroendocrine system cells. Mainly they...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687448/ https://www.ncbi.nlm.nih.gov/pubmed/23788913 http://dx.doi.org/10.5114/wo.2012.31764 |
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author | Gut, Paweł Fischbach, Jakub Kamiński, Grzegorz Ruchała, Marek |
author_facet | Gut, Paweł Fischbach, Jakub Kamiński, Grzegorz Ruchała, Marek |
author_sort | Gut, Paweł |
collection | PubMed |
description | The growing interest in neuroendocrine tumours is due to the dynamic growth of detection of this type of cancer. Neuroendocrine tumours (neuroendocrine neoplasms – NENs / neuroendocrine tumours – NETs) derive from glands, groups of endocrine cells and diffuse neuroendocrine system cells. Mainly they derive from the gastrointestinal tract (gastroenteropancreatic-neuroendocrine tumours – GEP-NETs). Currently the modified WHO classification from 2010 is widely used. An important element in the choice of treatment is histological maturity based on mitotic activity and on assessment of proliferation activity (Ki-67). The treatment of choice is surgery. In most cases, complete surgical removal is impossible because of the advanced staging at the time of diagnosis. In well-differentiated neoplasms where the expression of somatostatin receptors is expected, patients are qualified for somatostatin analogues therapy. Poorly differentiated lesions are qualified for chemotherapy. In the guidelines of ENETS (European Neuroendocrine Tumor Society) from 2007 the rules concerning monitoring depending on the WHO classification were specified. |
format | Online Article Text |
id | pubmed-3687448 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-36874482013-06-20 Contemporary methods of therapy and follow-up of neuroendocrine tumours of the gastrointestinal tract and the pancreas Gut, Paweł Fischbach, Jakub Kamiński, Grzegorz Ruchała, Marek Contemp Oncol (Pozn) Review The growing interest in neuroendocrine tumours is due to the dynamic growth of detection of this type of cancer. Neuroendocrine tumours (neuroendocrine neoplasms – NENs / neuroendocrine tumours – NETs) derive from glands, groups of endocrine cells and diffuse neuroendocrine system cells. Mainly they derive from the gastrointestinal tract (gastroenteropancreatic-neuroendocrine tumours – GEP-NETs). Currently the modified WHO classification from 2010 is widely used. An important element in the choice of treatment is histological maturity based on mitotic activity and on assessment of proliferation activity (Ki-67). The treatment of choice is surgery. In most cases, complete surgical removal is impossible because of the advanced staging at the time of diagnosis. In well-differentiated neoplasms where the expression of somatostatin receptors is expected, patients are qualified for somatostatin analogues therapy. Poorly differentiated lesions are qualified for chemotherapy. In the guidelines of ENETS (European Neuroendocrine Tumor Society) from 2007 the rules concerning monitoring depending on the WHO classification were specified. Termedia Publishing House 2012-11-20 2012 /pmc/articles/PMC3687448/ /pubmed/23788913 http://dx.doi.org/10.5114/wo.2012.31764 Text en Copyright © 2012 Termedia http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Gut, Paweł Fischbach, Jakub Kamiński, Grzegorz Ruchała, Marek Contemporary methods of therapy and follow-up of neuroendocrine tumours of the gastrointestinal tract and the pancreas |
title | Contemporary methods of therapy and follow-up of neuroendocrine tumours of the gastrointestinal tract and the pancreas |
title_full | Contemporary methods of therapy and follow-up of neuroendocrine tumours of the gastrointestinal tract and the pancreas |
title_fullStr | Contemporary methods of therapy and follow-up of neuroendocrine tumours of the gastrointestinal tract and the pancreas |
title_full_unstemmed | Contemporary methods of therapy and follow-up of neuroendocrine tumours of the gastrointestinal tract and the pancreas |
title_short | Contemporary methods of therapy and follow-up of neuroendocrine tumours of the gastrointestinal tract and the pancreas |
title_sort | contemporary methods of therapy and follow-up of neuroendocrine tumours of the gastrointestinal tract and the pancreas |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687448/ https://www.ncbi.nlm.nih.gov/pubmed/23788913 http://dx.doi.org/10.5114/wo.2012.31764 |
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