Effect of combination of rapamycin and cisplatin on human cervical carcinoma Hela cells

AIM OF THE STUDY: To evaluate the effect of combined use of rapamycin and cisplatin against Hela cells in vitro. MATERIAL AND METHODS: The inhibitory effects of rapamycin and cisplatin, used alone or combination, on the proliferation of Hela cell were measured with MTT assay and median-effect plot a...

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Detalles Bibliográficos
Autores principales: Han, Lu, Wu, Jie-Ling, Yang, Li-Xiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2013
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687477/
https://www.ncbi.nlm.nih.gov/pubmed/23788937
http://dx.doi.org/10.5114/wo.2012.32483
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author Han, Lu
Wu, Jie-Ling
Yang, Li-Xiao
author_facet Han, Lu
Wu, Jie-Ling
Yang, Li-Xiao
author_sort Han, Lu
collection PubMed
description AIM OF THE STUDY: To evaluate the effect of combined use of rapamycin and cisplatin against Hela cells in vitro. MATERIAL AND METHODS: The inhibitory effects of rapamycin and cisplatin, used alone or combination, on the proliferation of Hela cell were measured with MTT assay and median-effect plot analysis. RESULTS: Combined use of rapamycin and cisplatin significantly improved the chemotherapeutic effect against Hela cells. The inhibitory rates were dose-dependent. Rapamycin and cisplatin showed synergistic effects in the chemotherapy of Hela cells (q > 1.15, King's formula). CONCLUSIONS: Combined use of rapamycin and cisplatin significantly improves the chemotherapeutic effect against Hela cells.
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spelling pubmed-36874772013-06-20 Effect of combination of rapamycin and cisplatin on human cervical carcinoma Hela cells Han, Lu Wu, Jie-Ling Yang, Li-Xiao Contemp Oncol (Pozn) Original Paper AIM OF THE STUDY: To evaluate the effect of combined use of rapamycin and cisplatin against Hela cells in vitro. MATERIAL AND METHODS: The inhibitory effects of rapamycin and cisplatin, used alone or combination, on the proliferation of Hela cell were measured with MTT assay and median-effect plot analysis. RESULTS: Combined use of rapamycin and cisplatin significantly improved the chemotherapeutic effect against Hela cells. The inhibitory rates were dose-dependent. Rapamycin and cisplatin showed synergistic effects in the chemotherapy of Hela cells (q > 1.15, King's formula). CONCLUSIONS: Combined use of rapamycin and cisplatin significantly improves the chemotherapeutic effect against Hela cells. Termedia Publishing House 2013-01-04 2012 /pmc/articles/PMC3687477/ /pubmed/23788937 http://dx.doi.org/10.5114/wo.2012.32483 Text en Copyright © 2012 Termedia http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Paper
Han, Lu
Wu, Jie-Ling
Yang, Li-Xiao
Effect of combination of rapamycin and cisplatin on human cervical carcinoma Hela cells
title Effect of combination of rapamycin and cisplatin on human cervical carcinoma Hela cells
title_full Effect of combination of rapamycin and cisplatin on human cervical carcinoma Hela cells
title_fullStr Effect of combination of rapamycin and cisplatin on human cervical carcinoma Hela cells
title_full_unstemmed Effect of combination of rapamycin and cisplatin on human cervical carcinoma Hela cells
title_short Effect of combination of rapamycin and cisplatin on human cervical carcinoma Hela cells
title_sort effect of combination of rapamycin and cisplatin on human cervical carcinoma hela cells
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687477/
https://www.ncbi.nlm.nih.gov/pubmed/23788937
http://dx.doi.org/10.5114/wo.2012.32483
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