Cargando…

Non-Genetic Determinants of Mosquito Competence for Malaria Parasites

Understanding how mosquito vectors and malaria parasites interact is of fundamental interest, and it also offers novel perspectives for disease control. Both the genetic and environmental contexts are known to affect the ability of mosquitoes to support malaria development and transmission, i.e., ve...

Descripción completa

Detalles Bibliográficos
Autores principales: Lefèvre, Thierry, Vantaux, Amélie, Dabiré, Kounbobr R., Mouline, Karine, Cohuet, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688545/
https://www.ncbi.nlm.nih.gov/pubmed/23818841
http://dx.doi.org/10.1371/journal.ppat.1003365
_version_ 1782476223160516608
author Lefèvre, Thierry
Vantaux, Amélie
Dabiré, Kounbobr R.
Mouline, Karine
Cohuet, Anna
author_facet Lefèvre, Thierry
Vantaux, Amélie
Dabiré, Kounbobr R.
Mouline, Karine
Cohuet, Anna
author_sort Lefèvre, Thierry
collection PubMed
description Understanding how mosquito vectors and malaria parasites interact is of fundamental interest, and it also offers novel perspectives for disease control. Both the genetic and environmental contexts are known to affect the ability of mosquitoes to support malaria development and transmission, i.e., vector competence. Although the role of environment has long been recognized, much work has focused on host and parasite genetic effects. However, the last few years have seen a surge of studies revealing a great diversity of ways in which non-genetic factors can interfere with mosquito-Plasmodium interactions. Here, we review the current evidence for such environmentally mediated effects, including ambient temperature, mosquito diet, microbial gut flora, and infection history, and we identify additional factors previously overlooked in mosquito-Plasmodium interactions. We also discuss epidemiological implications, and the evolutionary consequences for vector immunity and parasite transmission strategies. Finally, we propose directions for further research and argue that an improved knowledge of non-genetic influences on mosquito-Plasmodium interactions could aid in implementing conventional malaria control measures and contribute to the design of novel strategies.
format Online
Article
Text
id pubmed-3688545
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-36885452013-07-01 Non-Genetic Determinants of Mosquito Competence for Malaria Parasites Lefèvre, Thierry Vantaux, Amélie Dabiré, Kounbobr R. Mouline, Karine Cohuet, Anna PLoS Pathog Review Understanding how mosquito vectors and malaria parasites interact is of fundamental interest, and it also offers novel perspectives for disease control. Both the genetic and environmental contexts are known to affect the ability of mosquitoes to support malaria development and transmission, i.e., vector competence. Although the role of environment has long been recognized, much work has focused on host and parasite genetic effects. However, the last few years have seen a surge of studies revealing a great diversity of ways in which non-genetic factors can interfere with mosquito-Plasmodium interactions. Here, we review the current evidence for such environmentally mediated effects, including ambient temperature, mosquito diet, microbial gut flora, and infection history, and we identify additional factors previously overlooked in mosquito-Plasmodium interactions. We also discuss epidemiological implications, and the evolutionary consequences for vector immunity and parasite transmission strategies. Finally, we propose directions for further research and argue that an improved knowledge of non-genetic influences on mosquito-Plasmodium interactions could aid in implementing conventional malaria control measures and contribute to the design of novel strategies. Public Library of Science 2013-06-20 /pmc/articles/PMC3688545/ /pubmed/23818841 http://dx.doi.org/10.1371/journal.ppat.1003365 Text en © 2013 Lefèvre et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Review
Lefèvre, Thierry
Vantaux, Amélie
Dabiré, Kounbobr R.
Mouline, Karine
Cohuet, Anna
Non-Genetic Determinants of Mosquito Competence for Malaria Parasites
title Non-Genetic Determinants of Mosquito Competence for Malaria Parasites
title_full Non-Genetic Determinants of Mosquito Competence for Malaria Parasites
title_fullStr Non-Genetic Determinants of Mosquito Competence for Malaria Parasites
title_full_unstemmed Non-Genetic Determinants of Mosquito Competence for Malaria Parasites
title_short Non-Genetic Determinants of Mosquito Competence for Malaria Parasites
title_sort non-genetic determinants of mosquito competence for malaria parasites
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688545/
https://www.ncbi.nlm.nih.gov/pubmed/23818841
http://dx.doi.org/10.1371/journal.ppat.1003365
work_keys_str_mv AT lefevrethierry nongeneticdeterminantsofmosquitocompetenceformalariaparasites
AT vantauxamelie nongeneticdeterminantsofmosquitocompetenceformalariaparasites
AT dabirekounbobrr nongeneticdeterminantsofmosquitocompetenceformalariaparasites
AT moulinekarine nongeneticdeterminantsofmosquitocompetenceformalariaparasites
AT cohuetanna nongeneticdeterminantsofmosquitocompetenceformalariaparasites