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Job Strain and Cardiovascular Disease Risk Factors: Meta-Analysis of Individual-Participant Data from 47,000 Men and Women

BACKGROUND: Job strain is associated with an increased coronary heart disease risk, but few large-scale studies have examined the relationship of this psychosocial characteristic with the biological risk factors that potentially mediate the job strain – heart disease association. METHODOLOGY AND PRI...

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Detalles Bibliográficos
Autores principales: Nyberg, Solja T., Fransson, Eleonor I., Heikkilä, Katriina, Alfredsson, Lars, Casini, Annalisa, Clays, Els, De Bacquer, Dirk, Dragano, Nico, Erbel, Raimund, Ferrie, Jane E., Hamer, Mark, Jöckel, Karl-Heinz, Kittel, France, Knutsson, Anders, Ladwig, Karl-Heinz, Lunau, Thorsten, Marmot, Michael G., Nordin, Maria, Rugulies, Reiner, Siegrist, Johannes, Steptoe, Andrew, Westerholm, Peter J. M., Westerlund, Hugo, Theorell, Töres, Brunner, Eric J., Singh-Manoux, Archana, Batty, G. David, Kivimäki, Mika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688665/
https://www.ncbi.nlm.nih.gov/pubmed/23840664
http://dx.doi.org/10.1371/journal.pone.0067323
Descripción
Sumario:BACKGROUND: Job strain is associated with an increased coronary heart disease risk, but few large-scale studies have examined the relationship of this psychosocial characteristic with the biological risk factors that potentially mediate the job strain – heart disease association. METHODOLOGY AND PRINCIPAL FINDINGS: We pooled cross-sectional, individual-level data from eight studies comprising 47,045 participants to investigate the association between job strain and the following cardiovascular disease risk factors: diabetes, blood pressure, pulse pressure, lipid fractions, smoking, alcohol consumption, physical inactivity, obesity, and overall cardiovascular disease risk as indexed by the Framingham Risk Score. In age-, sex-, and socioeconomic status-adjusted analyses, compared to those without job strain, people with job strain were more likely to have diabetes (odds ratio 1.29; 95% CI: 1.11–1.51), to smoke (1.14; 1.08–1.20), to be physically inactive (1.34; 1.26–1.41), and to be obese (1.12; 1.04–1.20). The association between job strain and elevated Framingham risk score (1.13; 1.03–1.25) was attributable to the higher prevalence of diabetes, smoking and physical inactivity among those reporting job strain. CONCLUSIONS: In this meta-analysis of work-related stress and cardiovascular disease risk factors, job strain was linked to adverse lifestyle and diabetes. No association was observed between job strain, clinic blood pressure or blood lipids.