Gene Knockout of 5-Lipoxygenase Rescues Synaptic Dysfunction and Improves Memory in the Triple-Transgenic Model of Alzheimer’s Disease

The 5-Lipoxygenase (5LO) is upregulated in Alzheimer’s disease (AD), and in vivo modulates the amyloidotic phenotype of APP transgenic mice. However, no data are available on the effects that 5LO has on synaptic function, integrity and cognition. To address this issue we used a genetic and a pharmac...

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Detalles Bibliográficos
Autores principales: Giannopoulos, Phillip F., Chu, Jin, Joshi, Yash B., Sperow, Margaret, Li, Jin-Luo, Kirby, Lynn G., Praticò, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688674/
https://www.ncbi.nlm.nih.gov/pubmed/23478745
http://dx.doi.org/10.1038/mp.2013.23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688674/
https://www.ncbi.nlm.nih.gov/pubmed/23478745
http://dx.doi.org/10.1038/mp.2013.23

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