Heme Oxygenase-1 Regulates Matrix Metalloproteinase MMP-1 Secretion and Chondrocyte Cell Death via Nox4 NADPH Oxidase Activity in Chondrocytes

Interleukin-1β (IL-1β) activates the production of reactive oxygen species (ROS) and secretion of MMPs as well as chondrocyte apoptosis. Those events lead to matrix breakdown and are key features of osteoarthritis (OA). We confirmed that in human C-20/A4 chondrocytes the NADPH oxidase Nox4 is the ma...

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Detalles Bibliográficos
Autores principales: Rousset, Francis, Nguyen, Minh Vu Chuong, Grange, Laurent, Morel, Françoise, Lardy, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688771/
https://www.ncbi.nlm.nih.gov/pubmed/23840483
http://dx.doi.org/10.1371/journal.pone.0066478

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688771/
https://www.ncbi.nlm.nih.gov/pubmed/23840483
http://dx.doi.org/10.1371/journal.pone.0066478

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