Structural Insights into the Folding Defects of Oncogenic pVHL Lead to Correction of Its Function In Vitro

Loss of function mutations in the von Hippel-Lindau (pVHL) tumor suppressor protein are tumorigenic. In silico analysis of the structure and folding of WT pVHL identified in its core an aromatic tetrahedron, essential for stabilizing the protein. The mutations disrupt the aromatic tetrahedron, leadi...

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Detalles Bibliográficos
Autores principales: Shmueli, Merav D., Schnaider, Lee, Rosenblum, Daniel, Herzog, Gal, Gazit, Ehud, Segal, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688787/
https://www.ncbi.nlm.nih.gov/pubmed/23840444
http://dx.doi.org/10.1371/journal.pone.0066333

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