Cytoplasmic TERT Associates to RNA Granules in Fully Mature Neurons: Role in the Translational Control of the Cell Cycle Inhibitor p15INK4B

The main role of Telomerase Reverse Transcriptase (TERT) is to protect telomere length from shortening during cell division. However, recent works have revealed the existence of a pool of TERT associated to mitochondria, where it plays a role in survival. We here show that in fully differentiated ne...

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Autores principales: Iannilli, Francesca, Zalfa, Francesca, Gartner, Annette, Bagni, Claudia, Dotti, Carlos G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688952/
https://www.ncbi.nlm.nih.gov/pubmed/23825548
http://dx.doi.org/10.1371/journal.pone.0066602
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author Iannilli, Francesca
Zalfa, Francesca
Gartner, Annette
Bagni, Claudia
Dotti, Carlos G.
author_facet Iannilli, Francesca
Zalfa, Francesca
Gartner, Annette
Bagni, Claudia
Dotti, Carlos G.
author_sort Iannilli, Francesca
collection PubMed
description The main role of Telomerase Reverse Transcriptase (TERT) is to protect telomere length from shortening during cell division. However, recent works have revealed the existence of a pool of TERT associated to mitochondria, where it plays a role in survival. We here show that in fully differentiated neurons the largest pool of cytoplasmic TERT associates to TIA1 positive RNA granules, where it binds the messenger RNA of the cyclin kinase inhibitor p15INK4B. Upon stress, p15INK4B and TERT dissociate and p15INK4B undergoes efficient translation, allowing its pro-survival function. These results unveil another mechanism implicated in the survival of fully differentiated neurons.
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spelling pubmed-36889522013-07-02 Cytoplasmic TERT Associates to RNA Granules in Fully Mature Neurons: Role in the Translational Control of the Cell Cycle Inhibitor p15INK4B Iannilli, Francesca Zalfa, Francesca Gartner, Annette Bagni, Claudia Dotti, Carlos G. PLoS One Research Article The main role of Telomerase Reverse Transcriptase (TERT) is to protect telomere length from shortening during cell division. However, recent works have revealed the existence of a pool of TERT associated to mitochondria, where it plays a role in survival. We here show that in fully differentiated neurons the largest pool of cytoplasmic TERT associates to TIA1 positive RNA granules, where it binds the messenger RNA of the cyclin kinase inhibitor p15INK4B. Upon stress, p15INK4B and TERT dissociate and p15INK4B undergoes efficient translation, allowing its pro-survival function. These results unveil another mechanism implicated in the survival of fully differentiated neurons. Public Library of Science 2013-06-18 /pmc/articles/PMC3688952/ /pubmed/23825548 http://dx.doi.org/10.1371/journal.pone.0066602 Text en © 2013 Dotti et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Iannilli, Francesca
Zalfa, Francesca
Gartner, Annette
Bagni, Claudia
Dotti, Carlos G.
Cytoplasmic TERT Associates to RNA Granules in Fully Mature Neurons: Role in the Translational Control of the Cell Cycle Inhibitor p15INK4B
title Cytoplasmic TERT Associates to RNA Granules in Fully Mature Neurons: Role in the Translational Control of the Cell Cycle Inhibitor p15INK4B
title_full Cytoplasmic TERT Associates to RNA Granules in Fully Mature Neurons: Role in the Translational Control of the Cell Cycle Inhibitor p15INK4B
title_fullStr Cytoplasmic TERT Associates to RNA Granules in Fully Mature Neurons: Role in the Translational Control of the Cell Cycle Inhibitor p15INK4B
title_full_unstemmed Cytoplasmic TERT Associates to RNA Granules in Fully Mature Neurons: Role in the Translational Control of the Cell Cycle Inhibitor p15INK4B
title_short Cytoplasmic TERT Associates to RNA Granules in Fully Mature Neurons: Role in the Translational Control of the Cell Cycle Inhibitor p15INK4B
title_sort cytoplasmic tert associates to rna granules in fully mature neurons: role in the translational control of the cell cycle inhibitor p15ink4b
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688952/
https://www.ncbi.nlm.nih.gov/pubmed/23825548
http://dx.doi.org/10.1371/journal.pone.0066602
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