Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry

Fixed, paraffin-embedded (FPE) tissues are a potentially rich resource for studying the role of NOTCH1 in cancer and other pathologies, but tests that reliably detect activated NOTCH1 (NICD1) in FPE samples have been lacking. Here, we bridge this gap by developing an immunohistochemical (IHC) stain...

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Detalles Bibliográficos
Autores principales: Kluk, Michael J., Ashworth, Todd, Wang, Hongfang, Knoechel, Birgit, Mason, Emily F., Morgan, Elizabeth A., Dorfman, David, Pinkus, Geraldine, Weigert, Oliver, Hornick, Jason L., Chirieac, Lucian R., Hirsch, Michelle, Oh, David J., South, Andrew P., Leigh, Irene M., Pourreyron, Celine, Cassidy, Andrew J., DeAngelo, Daniel J., Weinstock, David M., Krop, Ian E., Dillon, Deborah, Brock, Jane E., Lazar, Alexander J. F., Peto, Myron, Cho, Raymond J., Stoeck, Alexander, Haines, Brian B., Sathayanrayanan, Sriram, Rodig, Scott, Aster, Jon C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688991/
https://www.ncbi.nlm.nih.gov/pubmed/23825651
http://dx.doi.org/10.1371/journal.pone.0067306

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